CBR1 rs9024 genotype status impacts the bioactivation of loxoprofen in human liver
Related Experiment Video
Updated: Feb 9, 2026

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
Published on: April 27, 2015
Adolfo Quiñones-Lombraña1, Nasi Li2, Virginia Del Solar2
1University at Buffalo, The State University of New York (SUNY), Department of Pharmaceutical Sciences, Buffalo, New York, USA.
Abstract:
Loxoprofen is an anti-inflammatory drug that requires bioactivation into the trans-OH metabolite to exert pharmacological activity. Evidence suggests that carbonyl reductase 1 (CBR1) is important during the bioactivation of loxoprofen. This study examined the impact of the functional single nucleotide polymorphism CBR1 rs9024 on the bioactivation of loxoprofen in a collection of human liver samples. The synthesis ratios of trans-OH loxoprofen/cis-OH loxoprofen were 33% higher in liver cytosols from donors homozygous for the CBR1 rs9024 G allele in comparison with the ratios in samples from donors with heterozygous GA genotypes. Complementary studies examined the impact of CBR1 rs9024 on the bioactivation of loxoprofen in lymphoblastoid cell lines. CBR1 rs9024 genotype status impacts the synthesis of the bioactive trans-OH metabolite of loxoprofen in human liver.
Related Concept Videos
Impact of Groups on Groups
Marcia's Theory of Identity Status
Impact
When particles with different initial velocities collide, they induce deformation by applying equal and opposite impulses. At the point of maximum deformation, the particles move together with...
Impact of Groups on Individuals
Impact of Individuals on a Group
Impact of Schemas

