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Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
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Substrate Sequence Determines Catalytic Activities, Domain-Binding Preferences, and Allosteric Mechanisms in Pin1

Mohamed Momin, Xin-Qiu Yao, Waygen Thor

    The Journal of Physical Chemistry. B
    |June 1, 2018
    PubMed
    Summary

    Pin1 isomerase function depends on substrate sequence. This study unifies divergent views on its WW domain, revealing sequence-dictated allosteric effects crucial for Pin1

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