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Related Experiment Video

Updated: Feb 9, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Mast cells in the developing avian eye.

Ana Paula Girol¹, Sonia Maria Oliani², Ricardo Luiz Smith¹

¹Department of Morphology, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04023-900, Brazil.

Journal of Morphology

|June 2, 2018

Summary

Mast cells are found in specific eye regions of chickens, with their numbers and granule characteristics changing during development. These cells likely play a role in aqueous humor dynamics.

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Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Area of Science:

Ophthalmology
Cell Biology
Histology

Background:

Mast cells are immune cells involved in inflammatory responses.
Their presence and function in ocular tissues are not fully understood.
Gallus domesticus (chicken) provides a model for avian eye development.

Purpose of the Study:

To investigate the distribution and ultrastructural characteristics of mast cells in the developing and adult chicken eye.
To explore the potential physiological roles of ocular mast cells.

Main Methods:

Histological and ultrastructural examination of chicken eyes at different developmental stages.
Localization of mast cells using light and electron microscopy.
Analysis of mast cell granule morphology and fluorescence.

Main Results:

Mast cells are present in the anterior uvea by embryonic day 13 (stage 39 HH) and in adult tissues like sclera, uvea, pectinate ligament, and conjunctiva.
Mast cells are absent in the cornea, retina, and pecten oculi.
Maturing mast cells show increasing metachromatic granules and fluorescence; mature cells have diverse granule structures.

Conclusions:

Mast cells inhabit specific anterior segment ocular tissues in chickens.
Their presence suggests a role in ocular development and aqueous humor outflow regulation.
Ocular mast cells may modulate blood-aqueous humor exchange via granule-mediated chemical mediators.