Related Experiment Video
Updated: Feb 9, 2026
07:56
Preparation of Liquid Crystal Networks for Macroscopic Oscillatory Motion Induced by Light
Published on: September 20, 2017
12.2K
Oscillatory Dynamics of P53 Network With Time Delays
Conghua Wang1, Fang Yan1, Yuan Zhang2
1College of Mathematics, Yunnan Normal University, Kunming 650500, China.
Combinatorial Chemistry & High Throughput Screening
|June 2, 2018
Summary
Time delays in gene expression, specifically in p53 networks, can induce oscillations that regulate cell fate. Delay length controls oscillation amplitude and period, crucial for genetic network dynamics.
Area of Science:
- Systems Biology
- Molecular Biology
- Biophysics
Background:
- p53 protein dynamics are critical for cell fate decisions.
- Gene expression involves time delays impacting genetic network behavior.
- The role of delays in p53 network oscillations remains incompletely understood.
Purpose of the Study:
- To develop an integrated model of the p53 network incorporating time delays.
- To investigate how time delays influence oscillatory dynamics and Hopf bifurcations.
- To analyze the impact of delays on p53 network component expression levels.
Main Methods:
- Development of a five-component model with two time delays.
- Analysis of characteristic equations to determine Hopf bifurcation.
- Numerical simulations to illustrate model behavior and parameter effects.
Main Results:
- Transcriptional and translational delays induce oscillations via supercritical Hopf bifurcation.
- Time delay duration directly controls oscillation amplitude and period.
- Specific ranges of model parameters are necessary for sustained oscillations.
Conclusions:
- Time delays are key drivers of oscillatory behavior in the p53 network.
- Delay duration offers a mechanism to tune p53 network dynamics.
- Understanding these delay-induced oscillations is vital for cell fate regulation.
Related Concept Videos
02:26Protein Networks
4.6K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.6K
02:26Protein Networks
2.9K
2.9K
02:18Network Covalent Solids
16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
02:20Dynamic Equilibrium
63.1K
A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
63.1K
01:25Network Function of a Circuit
871
Frequency response analysis in electrical circuits provides vital insights into a circuit's behavior as the frequency of the input signal changes. The transfer function, a mathematical tool, is instrumental in understanding this behavior. It defines the relationship between phasor output and input and comes in four types: voltage gain, current gain, transfer impedance, and transfer admittance. The critical components of the transfer function are the poles and zeros.
871
01:24Sequence Networks of Rotating Machines
503
A Y-connected synchronous generator, grounded through a neutral impedance, is designed to produce balanced internal phase voltages with only positive-sequence components. The generator's sequence networks include a source voltage that is exclusively in the positive-sequence network. The sequence components of line-to-ground voltages at the generator terminals illustrate this configuration.
Zero-sequence current induces a voltage drop across the generator's neutral impedance and other...
Zero-sequence current induces a voltage drop across the generator's neutral impedance and other...
503