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Production of Single Tracks of Ti-6Al-4V by Directed Energy Deposition to Determine the Layer Thickness for Multilayer Deposition
Published on: March 13, 2018
Cellular response to nano-structured Zr and ZrO2 alloyed layers on Ti-6Al-4V
Xiangyu Zhang1, Guannan Zhang2, Jianfang Li2
1College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, China; Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China.
Abstract:
The surface topography of biomaterials is known to influence cellular response such as adhesion, spreading and differentiation. In this work, the behavior of osteoblasts and endothelial cells on nano-structured Zr and micro/nano-structured ZrO2 alloyed layers of Ti-6Al-4V (TC4) was investigated. Zr alloyed layer (Zr@TC4) decreases the hydrophilicity whereas ZrO2 alloyed layers (ZrO2@TC4) is more hydrophilic than TC4 and more proteins adsorb on ZrO2@TC4 followed by Zr@TC4. The cells proliferate steadily on the smooth TC4 and nano-structured Zr@TC4 surfaces and the osteoblast activity is more pronounced on Zr@TC4 than TC4. The micro/nano-structured surface on ZrO2@TC4 restricts cellular adhesion and spreading independent of the surface wettability and protein adsorption. The findings provide insights into the design of micro/nano-structured biomaterials and interfaces with controlled tissue response.
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