Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Membrane Proteins01:16

Introduction to Membrane Proteins

81.4K
The cell membrane, or plasma membrane, is an ever-changing landscape. It is described as a fluid mosaic where various macromolecules are embedded in the phospholipid bilayer. Among the macromolecules are proteins. The protein content varies across cell types. For example, mitochondrial inner membranes contain ~76% protein content, while myelin contains ~18% protein content. Individual cells contain many types of membrane proteins—red blood cells contain over 50—and different cell...
81.4K
What are Membranes?01:54

What are Membranes?

192.5K
A key characteristic of life is the ability to separate the external environment from the internal space. To do this, cells have evolved semi-permeable membranes that regulate the passage of biological molecules. Additionally, the cell membrane defines a cell’s shape and interactions with the external environment. Eukaryotic cell membranes also serve to compartmentalize the internal space into organelles, including the endomembrane structures of the nucleus, endoplasmic reticulum and...
192.5K
What are Membranes?01:24

What are Membranes?

19.1K
A cell's plasma membrane demarcates the cell's borders and determines the nature of its interaction with the environment. Cells exclude certain substances, take in others, and excrete some others in controlled quantities. The plasma membrane must be flexible to allow certain cells, such as red and white blood cells, to change their shape while passing through narrow capillaries. These are the more obvious plasma membrane functions. In addition, the plasma membrane's surface carries...
19.1K
The Resting Membrane Potential01:21

The Resting Membrane Potential

143.1K
Overview
143.1K
Sustainable Development01:43

Sustainable Development

15.2K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.2K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.2K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autopsy detection of Pneumatosis Cystoides Intestinalis in a patient with end-stage renal failure from autosomal dominant polycystic kidney disease undergoing dialysis: a case report.

Oxford medical case reports·2025
Same author

Single-cell RNA sequencing reveals genes relevant to periodontal therapy and periodontitis.

Physiological genomics·2025
Same author

Perivascular cells function as key mediators of mechanical and structural changes in vascular capillaries.

Science advances·2025
Same author

Publisher Correction: Integrin signalling in joint development, homeostasis and osteoarthritis.

Nature reviews. Rheumatology·2024
Same author

Integrin signalling in joint development, homeostasis and osteoarthritis.

Nature reviews. Rheumatology·2024
Same author

Microtubule-dependent apical polarization of basement membrane matrix mRNAs in mouse epithelial cells.

Cells & development·2023

Related Experiment Video

Updated: Feb 9, 2026

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases
13:18

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases

Published on: September 20, 2016

10.2K

Basement Membranes in Development and Disease.

Rei Sekiguchi1, Kenneth M Yamada1

  • 1Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, United States.

Current Topics in Developmental Biology
|June 2, 2018
PubMed
Summary
This summary is machine-generated.

Basement membranes, crucial extracellular matrices, dynamically change during development and disease. Understanding these dynamics in model organisms offers insights into biological mechanisms and therapeutic strategies.

Keywords:
Basement membraneBasement membrane poresCancerCell migrationDevelopmentExtracellular matrixInvasionMorphogenesisProliferation

More Related Videos

Ultrathin Porated Elastic Hydrogels As a Biomimetic Basement Membrane for Dual Cell Culture
11:34

Ultrathin Porated Elastic Hydrogels As a Biomimetic Basement Membrane for Dual Cell Culture

Published on: December 26, 2017

8.2K
Confocal and Super-Resolution Imaging of Polarized Intracellular Trafficking and Secretion of Basement Membrane Proteins During Drosophila Oogenesis
10:41

Confocal and Super-Resolution Imaging of Polarized Intracellular Trafficking and Secretion of Basement Membrane Proteins During Drosophila Oogenesis

Published on: May 19, 2022

2.6K

Related Experiment Videos

Last Updated: Feb 9, 2026

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases
13:18

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases

Published on: September 20, 2016

10.2K
Ultrathin Porated Elastic Hydrogels As a Biomimetic Basement Membrane for Dual Cell Culture
11:34

Ultrathin Porated Elastic Hydrogels As a Biomimetic Basement Membrane for Dual Cell Culture

Published on: December 26, 2017

8.2K
Confocal and Super-Resolution Imaging of Polarized Intracellular Trafficking and Secretion of Basement Membrane Proteins During Drosophila Oogenesis
10:41

Confocal and Super-Resolution Imaging of Polarized Intracellular Trafficking and Secretion of Basement Membrane Proteins During Drosophila Oogenesis

Published on: May 19, 2022

2.6K

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Extracellular Matrix Research

Background:

  • Basement membranes are specialized extracellular matrices with diverse, tissue-specific functions.
  • Their composition and structure change dynamically throughout life, especially during development.
  • These changes are critical for numerous developmental processes, involving molecular and mechanical factors.

Purpose of the Study:

  • To review the dynamic transformations of basement membranes during development and disease.
  • To explore the role of basement membranes in cell transmigration and its link to disease invasion.
  • To highlight the importance of basement membrane research for biological insights and therapeutics.

Main Methods:

  • Review of existing literature on basement membrane dynamics.
  • Comparative analysis across model organisms: Caenorhabditis elegans, Drosophila, and vertebrates.
  • Focus on developmental and disease-related changes in basement membrane structure and function.

Main Results:

  • Basement membranes undergo significant transformations during animal development, influencing various mechanisms.
  • Cell transmigration through basement membranes is a key process, relevant to both development and disease.
  • Dysregulation of cells and extracellular matrices distinguishes disease processes from normal development.

Conclusions:

  • Basement membrane dynamics are central to understanding fundamental biological processes.
  • Research into basement membranes can yield novel therapeutic approaches for diseases.
  • Studying basement membranes in model organisms provides valuable insights into conserved mechanisms.