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High NUSAP1 expression predicts poor prognosis in colon cancer
Zhaoxiu Liu1, Chengqi Guan1, Cuihua Lu1
1Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Pathology, Research and Practice
|June 2, 2018
Summary
Nucleolar and spindle-associated protein 1 (NUSAP1) is overexpressed in colon cancer. High NUSAP1 expression indicates a poor prognosis and serves as an independent risk factor for patient survival.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Nucleolar and spindle-associated protein 1 (NUSAP1) is a key regulator of mitosis.
- Aberrant NUSAP1 expression is linked to mitotic dysfunction and cancer development.
- Understanding NUSAP1's role in colon cancer is crucial for prognosis.
Purpose of the Study:
- To investigate the clinical significance of NUSAP1 expression in colon cancer.
- To determine if NUSAP1 expression correlates with clinicopathological features.
- To evaluate NUSAP1 as a prognostic marker in colon cancer.
Main Methods:
- Immunohistochemistry to quantify NUSAP1 protein levels in colon tumors.
- RT-qPCR to measure NUSAP1 mRNA expression.
- Statistical analyses including Kaplan-Meier and Cox proportional hazards models.
Main Results:
- NUSAP1 protein and mRNA levels were significantly elevated in colon tumors compared to adjacent non-cancerous tissues.
- High NUSAP1 expression correlated with advanced histopathological grading, deeper invasion, lymph node metastasis, and higher TNM stage.
- Patients with high NUSAP1 expression had significantly lower overall survival rates.
Conclusions:
- NUSAP1 is significantly overexpressed in colon cancer tissues.
- Elevated NUSAP1 expression is an independent predictor of poor prognosis in colon cancer patients.
- NUSAP1 may serve as a valuable biomarker for risk stratification in colon cancer.
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