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Association of Circulating Chemerin With Subclinical Parameters of Atherosclerosis: Results of a Population-Based

Stephanie Zylla1,2, Marcus Dörr3,2, Henry Völzke4,2

  • 1From the Institute of Clinical Chemistry and Laboratory Medicine (S.Z., M.N., N.F.) stephanie.zylla@uni-greifswald.de.

Arteriosclerosis, Thrombosis, and Vascular Biology
|June 2, 2018
PubMed

Insights

Plasma chemerin levels show an inverse association with ankle-brachial index, a marker of peripheral artery disease. This finding suggests chemerin

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Metabolic Syndrome

Background:

  • Chemerin is linked to inflammation and metabolic syndrome, key atherosclerosis risk factors.
  • Existing research on chemerin's role in atherosclerosis presents conflicting results.
  • Investigating chemerin's association with subclinical atherosclerosis is crucial.

Purpose of the Study:

  • To examine the relationship between plasma chemerin levels and subclinical atherosclerosis measures.
  • To clarify the role of chemerin in different stages and arterial regions of atherosclerosis.

Main Methods:

  • Analysis of data from 4003 participants in the Study of Health in Pomerania (SHIP).
  • Utilized linear and logistic regression models to assess associations with atherosclerotic parameters.
  • Adjusted for metabolic and inflammatory factors to refine findings.

Main Results:

  • A significant inverse association was found between chemerin and ankle-brachial index (ABI).
  • Increased chemerin levels correlated with a higher likelihood of low ABI.
  • No significant association was observed between chemerin and carotid intima-media thickness, plaque, or stenosis after adjustments.

Conclusions:

  • A modest inverse association exists between chemerin and ABI, independent of metabolic and inflammatory markers.
  • Chemerin's association with atherosclerosis may vary by arterial region and disease stage.
  • Further research is needed to elucidate chemerin's specific role in cardiovascular risk stratification.
Abstract

Keywords:
adipokinesankle-brachial indexatherosclerosiscarotid intima-media thicknesschemerininflammationrisk factors

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