Related Experiment Video
Updated: Feb 9, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
X Marks the Spot: Mapping Similarity Between Clinical Trial Cohorts and US Counties
Matthew C Lenert1, Dara E Mize2, Colin G Walsh2
1Vanderbilt University, Nashville, TN.
Abstract:
When patients and doctors collaborate to make healthcare decisions, they rely on clinical trial results to guide discussions. Trials are designed to recruit diverse participants. The question remains - how well do trial results apply to me or to people who live in our area? This study compared one complete clinical trial dataset (SPRINT) and one published study (ACCORD) to the Community Health Status Indicators dataset to assess the similarity of the trial populations to US county populations. Counties up to 495 miles to the closest SPRINT trial site and up to 712 miles to the closest ACCORD trial site had populations that were significantly more similar to the study cohort than counties farther away. The investigators detail a generalizable method for both assessing recruitment gaps in large multicenter trials and creating maps for clinicians to provide intuition on trial applicability in their area.
Related Concept Videos
Clinical Trials
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview
Statistical Software for Data Analysis and Clinical Trials
Causes of Similarity-Dissimilarity Effect
Bone Markings
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
Factors Influencing Attraction III: Similarity

