Dasatinib-Induced Rhabdomyolysis in a 33-Year-Old Patient with Chronic Myeloid Leukemia

Area of Science:

• Medical Case Study
• Toxicology
• Hematology

Background:

• Rhabdomyolysis is a critical medical condition characterized by skeletal muscle breakdown.
• Causes include trauma, crush injuries, and adverse drug reactions.
• Human immunodeficiency virus (HIV) and chronic myeloid leukemia (CML) are significant comorbidities.

Observation:

• A 33-year-old male patient presented with severe, life-threatening rhabdomyolysis.
• The patient had a history of HIV and newly diagnosed CML.
• A rare offending agent was identified as the cause of rhabdomyolysis.

Findings:

• The case details a rare instance of drug-induced rhabdomyolysis.
• The interaction between HIV, CML, and the causative agent is explored.
• Severe muscle breakdown was confirmed as the primary clinical manifestation.

Implications:

• This case underscores the importance of identifying rare medication side effects.
• It highlights potential drug interactions in patients with complex conditions like HIV and CML.
• Awareness of such rare causes is crucial for timely diagnosis and management of rhabdomyolysis.