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Updated: Feb 9, 2026

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
Published on: December 16, 2013
Cutaneous Basal Cell Carcinoma with Lymph Node and Pulmonary Metastases
Renate U Wahl1, Claudio Cacchi2, Albert Rübben1
1Department of Dermatology, Euregional Skin Cancer Center, University Hospital of the RWTH-Aachen, Aachen, Germany.
Abstract:
Basal cell carcinoma (BCC) is the most common skin cancer. Metastatic BCC is an extraordinary rare finding observed in only 0.5% of all cases. Until the introduction of the small molecule hedgehog inhibitor vismodegib, patients with metastatic BCC were treated with chemotherapy, most frequently platinum-based with mixed responses to therapy. We present the case of a 55-year-old Caucasian man who suffered from BCC on his left arm with lymph node and pulmonary metastases. Sonic hedgehog blockade with vismodegib only induced a short remission, and the patient succumbed to the cancer.
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