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Mean Platelet Volume and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Zhongwei Zhou1, Hongmei Chen1, Mingzhong Sun1

  • 1Department of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu 224001, China.

Journal of Diabetes Research
|June 2, 2018
PubMed
Abstract

Insights

Mean platelet volume (MPV) is significantly higher in patients with gestational diabetes mellitus (GDM). This finding suggests MPV may serve as a useful predictive marker for GDM in clinical practice.

Area of Science:

  • Reproductive Medicine
  • Hematology
  • Metabolic Disorders

Background:

  • Gestational diabetes mellitus (GDM) is a common pregnancy complication with potential long-term health implications for both mother and child.
  • Platelet indices, including mean platelet volume (MPV), are increasingly recognized as potential biomarkers for various inflammatory and metabolic conditions.
  • Understanding the relationship between MPV and GDM is crucial for identifying potential diagnostic or predictive markers.

Purpose of the Study:

  • To systematically evaluate the association between mean platelet volume (MPV) and gestational diabetes mellitus (GDM).
  • To synthesize existing evidence through a meta-analysis to determine the overall trend of MPV in GDM patients compared to healthy pregnant women.

Main Methods:

  • A comprehensive literature search was conducted across major databases (PubMed, EMBASE, Web of Science, Cochrane Library) up to September 2017.
  • A random-effects model was employed to calculate pooled standardized mean differences (SMD) and 95% confidence intervals (CI) for MPV levels.
  • Nineteen studies involving 1361 GDM patients and 1911 controls were included in the meta-analysis.

Main Results:

  • A statistically significant increase in MPV was observed in GDM patients compared to healthy pregnant women (SMD: 0.79; 95% CI: 0.43-1.16; P < 0.001).
  • Subgroup analyses confirmed this trend across different trimesters, ethnicities (Turkish, Italian), and diagnostic criteria (Carpenter and Coustan).
  • Higher MPV was also noted in cross-sectional studies, though heterogeneity and potential publication bias were acknowledged, with sensitivity analyses showing robust results.

Conclusions:

  • Gestational diabetes mellitus is consistently associated with elevated mean platelet volume.
  • The findings strengthen the clinical evidence supporting MPV as a potential predictive marker for GDM.
  • Further research may explore the mechanistic link and clinical utility of MPV in GDM management.

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