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Global lung function initiative 2012 reference values for spirometry in Asian Americans.

Jingzhou Zhang1,2, Xiao Hu1,3, Xinlun Tian1

  • 1Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, 100730, China.

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|June 2, 2018
PubMed
Summary
This summary is machine-generated.

The Global Lung Function Initiative 2012 (GLI-2012) equations for mixed ethnic origins showed good performance for spirometry in Asian Americans. Specific equations for North East and South East Asians were less suitable, indicating the need for further research.

Keywords:
Asian AmericansLLNLung functionSpirometryZ-score

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Area of Science:

  • Pulmonary Medicine
  • Clinical Diagnostics
  • Population Health

Background:

  • Spirometry reference values tailored for Asian Americans are currently lacking.
  • The applicability of Global Lung Function Initiative 2012 (GLI-2012) equations for spirometry assessment in Asian Americans remains unevaluated.

Purpose of the Study:

  • To evaluate the suitability of relevant GLI-2012 equations for spirometry in Asian Americans.
  • To assess the performance of GLI-2012 equations for North East Asians, South East Asians, and individuals of mixed ethnic origin in this population.

Main Methods:

  • Utilized spirometry data from non-smoking Asian subjects in the National Health and Nutrition Examination Survey (NHANES) 2011-2012.
  • Constructed Z-scores for forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC using GLI-2012 equations for specific Asian subgroups and a mixed ethnic group.
  • Determined the proportion of subjects with spirometry data below the lower limit of normal (LLN) for each equation.

Main Results:

  • GLI-2012 equations for mixed ethnic origins demonstrated mean Z-scores near zero and standard deviations near one, with 6.0-6.4% of subjects below LLN for FEV1/FVC.
  • North East Asian equations yielded mean Z-scores for FEV1 and FVC below -0.5.
  • South East Asian equations showed mean FEV1/FVC Z-scores significantly below zero for both men and women.

Conclusions:

  • GLI-2012 equations designated for mixed ethnic groups provide an adequate fit for spirometry data in Asian Americans.
  • Further research with larger sample sizes is recommended to validate these findings and refine spirometry reference values for diverse Asian American populations.