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Clinical and epidemiological features of Heart-Hand Syndrome: a hospital-based study in China

Yaobin Yin1, Jianguang Ji2, Yan Borné3

  • 1Department of hand surgery, Beijing Ji Shui Tan Hospital, Xin jie kou dong jie 31, Xi Cheng Qu, 100035, Beijing, China. yinyaobin586@163.com.

Scientific Reports
|June 2, 2018
PubMed

Insights

Heart-hand syndrome (HHS) involves congenital heart disease and upper limb malformations. In China, 11.8% of patients with limb defects had heart abnormalities, highlighting the need for pre-operative cardiac screening.

Area of Science:

  • Cardiology
  • Genetics
  • Orthopedics

Background:

  • Heart-hand syndrome (HHS) is a complex condition linking congenital heart defects with upper limb malformations.
  • Understanding the prevalence and specific manifestations of HHS in diverse populations is crucial for clinical management.

Purpose of the Study:

  • To investigate the clinical and epidemiological characteristics of Heart-hand syndrome in China.
  • To determine the incidence of congenital heart disease among patients with congenital upper limb malformations.

Main Methods:

  • A retrospective review of 1462 patients with congenital upper limb malformations treated at Beijing Ji Shui Tan hospital (2013-2016).
  • Inclusion criteria involved abnormal ultrasonic cardiogram and/or electrocardiogram (ECG) findings.
  • Analysis of patient medical records to identify cardiac and limb defect types.

Main Results:

  • 172 out of 1462 patients (11.8%) exhibited abnormal cardiac findings (ultrasonic cardiogram or ECG).
  • Congenital heart structure abnormalities were found in 121 patients, with tricuspid regurgitation being most common (43.8%).
  • Abnormal ECG patterns were observed in 51 patients (43.1%).

Conclusions:

  • A significant rate of congenital heart disease co-occurs with upper limb malformations in the studied Chinese population.
  • Pre-operative cardiac screening is essential for patients with congenital upper limb malformations to prevent surgical complications.
  • Enhanced awareness among surgeons and anesthetists regarding this comorbidity is recommended.

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