Related Experiment Video
Updated: Feb 9, 2026
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
Minimally Invasive Versus Open Primary Resection for Retroperitoneal Soft Tissue Sarcoma: A Propensity-Matched Study
Faiz Gani1, Utkarsh Goel1, Alex B Blair1
1Division of Surgical Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background:
Although well described for gastrointestinal and pelvic cancers, use of minimally invasive surgery (MIS) for the management of retroperitoneal soft tissue sarcoma (RPS) remains unknown. The current study aimed to describe patterns of MIS use and assess the association between MIS and clinical outcomes among patients undergoing surgery for RPS.
Methods:
Patients undergoing a primary resection for RPS between 2010 and 2014 were identified using the National Cancer Database. Multivariable logistic and Cox proportional hazards models were used to assess the association between use of MIS and clinical outcomes. Sensitivity analysis was performed using propensity score-matching (PSM).
Results:
This study identified 3844 patients who met the inclusion criteria. Of these patients, 89.3% (n = 3432) underwent an open surgery, whereas 10.7% (n = 412) underwent MIS. The patients undergoing MIS were more likely to present with smaller tumors (open vs MIS: median tumor size, 17 cm; interquartile range [IQR, 9.8-26.0] vs 10.5 cm [IQR, 6.5-18.0]) and to undergo surgery at community hospitals (26.8% vs 36.1%; both P < 0.001). Although MIS was associated with a shorter hospital length of stay [LOS] (median LOS, 6 days [IQR, 5-9 days] vs 4 days [IQR, 2-7]; P < 0.001), postoperative mortality and overall survival were comparable between the two treatment groups (all P > 0.05). These findings were confirmed using PSM.
Conclusions:
MIS was associated with a shorter LOS, however, postoperative mortality and overall survival were comparable by operative approach. Future research is required to evaluate the use of MIS for the management of RPS. Policies are required to ensure that patients receive care in accordance with best practices and recommended guidelines.
Insights
Minimally invasive surgery (MIS) for retroperitoneal soft tissue sarcoma (RPS) is associated with shorter hospital stays but similar survival and mortality rates compared to open surgery. Further research is needed to fully evaluate MIS for RPS management.
Area of Science:
- Surgical Oncology
- Sarcoma Research
- Minimally Invasive Surgery
Background:
- Minimally invasive surgery (MIS) is well-established for gastrointestinal and pelvic cancers.
- The application and outcomes of MIS for retroperitoneal soft tissue sarcoma (RPS) are not well-defined.
Purpose of the Study:
- To describe the utilization patterns of MIS in RPS management.
- To assess the association between MIS and clinical outcomes in RPS patients.
Main Methods:
- Retrospective analysis of 3844 patients undergoing primary RPS resection (2010-2014) from the National Cancer Database.
- Multivariable logistic and Cox proportional hazards models were employed.
- Propensity score-matching (PSM) was used for sensitivity analysis.
Main Results:
- 10.7% of patients underwent MIS, while 89.3% had open surgery.
- MIS was associated with smaller tumors and shorter hospital length of stay (LOS).
- Postoperative mortality and overall survival were comparable between MIS and open surgery groups, confirmed by PSM.
Conclusions:
- MIS for RPS is linked to reduced hospital LOS.
- Operative approach (MIS vs. open) did not significantly impact postoperative mortality or overall survival.
- Further investigation into MIS for RPS is warranted, alongside policy development for best practice adherence.
Related Concept Videos
01:03Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:17Sign Test for Matched Pairs
To conduct the sign test, we first calculate the differences in...
01:26National Nursing Organizations I
01:30National Nursing Organizations II
The AACN emphasizes a healthy work environment through six standards to achieve an optimal patient outcome. The standards are appropriate staffing, meaningful recognition, collaboration, authentic leadership, effective communication, and decision-making. In addition, AACN provides certification programs, webinars, journals, and...
02:43Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
01:09Wilcoxon Signed-Ranks Test for Matched Pairs