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Epilepsy and Seizures: Overview01:24

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Related Experiment Video

Updated: Feb 9, 2026

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
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New-onset epilepsy in the elderly.

Lily Chi Vu1, Loretta Piccenna2, Patrick Kwan1,2

  • 1Melbourne Brain Centre at the Royal Melbourne Hospital; Departments of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, 3050, Australia.

British Journal of Clinical Pharmacology
|June 2, 2018
PubMed
Summary
This summary is machine-generated.

New-onset epilepsy is most common in adults 60 and older. Newer antiepileptic drugs show better tolerance, but more research is needed on effective treatments and psychosocial impacts in this population.

Keywords:
antiepileptic drugselderlynew-onset epilepsypsychosocialrandomized controlled trialstreatment

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Area of Science:

  • Geriatric Medicine
  • Neurology
  • Epileptology

Background:

  • The incidence of new-onset epilepsy is highest in individuals aged 60 years and older.
  • The aging global population is experiencing a rise in new-onset epilepsy cases.
  • Existing reviews often lack a specific focus on epilepsy in older adults.

Purpose of the Study:

  • To review the causes, treatment, prognosis, and psychosocial impact of new-onset epilepsy in individuals aged 60 years and above.
  • To identify evidence-based treatment strategies for epilepsy in the elderly population.
  • To highlight gaps in current research and clinical guidelines for geriatric epilepsy.

Main Methods:

  • A comprehensive search of medical electronic databases and reference lists was conducted.
  • Inclusion criteria were applied to identify relevant studies focusing on new-onset epilepsy in individuals aged ≥60 years.
  • A total of 22 studies met the inclusion criteria for the review.

Main Results:

  • Four randomized clinical trials (RCTs) indicated newer antiepileptic drugs (e.g., lamotrigine, levetiracetam) are better tolerated in older adults.
  • One study suggested surgical resection may be effective for uncontrolled seizures in this demographic.
  • Five studies reported significant cognitive impairments and psychological issues (depression, anxiety, fatigue) in older adults with new-onset epilepsy.
  • Limited evidence exists for managing epilepsy in patients with Alzheimer's disease.

Conclusions:

  • Treatment choices for new-onset epilepsy in older adults must consider population-specific features.
  • Cognitive and psychiatric screening prior to treatment initiation is recommended.
  • There is a critical need for more RCTs on effective, low-side-effect treatments and further research into psychosocial effects and long-term outcomes for this population.
  • Formal clinical practice guidelines for managing new-onset epilepsy in individuals aged 60 and older are currently lacking.