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Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
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Ligand Binding and Linkage00:49

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Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

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Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
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Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
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Aptamer-based multifunctional ligand-modified UCNPs for targeted PDT and bioimaging.

Weijia Hou1, Yuan Liu, Ying Jiang

  • 1Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Health Cancer Center, University of Florida, Gainesville, FL 32611-7200, USA. tan@chem.ufl.edu.

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Researchers developed a multifunctional aptamer ligand for upconversion nanoparticles (UCNPs). This enables targeted cancer therapy by facilitating phase transfer, photosensitizer loading, and cell targeting for potent cytotoxicity.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Research

Background:

  • Upconversion nanoparticles (UCNPs) offer unique optical properties for biomedical applications.
  • Targeted cancer therapy requires efficient drug delivery and selective cancer cell destruction.
  • Developing multifunctional nanocarriers is crucial for advanced therapeutic strategies.

Purpose of the Study:

  • To design an aptamer-based multifunctional ligand for UCNPs.
  • To enable simultaneous phase transfer, photosensitizer loading, and cancer cell targeting.
  • To create a novel photodynamic therapy (PDT) nanodrug with enhanced efficacy and selectivity.

Main Methods:

  • Conjugation of an aptamer-based multifunctional ligand to UCNP surfaces.
  • Covalent loading of photosensitizers (PS) onto the functionalized UCNPs.
  • In vitro evaluation of cancer cell uptake and cytotoxicity.

Main Results:

  • The aptamer ligand facilitated phase transfer and PS loading in a single step.
  • The resulting nanodrug selectively targeted and internalized into cancer cells.
  • The nanodrug demonstrated highly efficient and selective cancer cell cytotoxicity.

Conclusions:

  • The aptamer-based multifunctional ligand provides a versatile platform for UCNP functionalization.
  • This approach enables the development of effective and targeted PDT nanodrugs.
  • The designed nanodrug shows significant potential for selective cancer treatment.