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NMR Relaxometry to Characterize the Drug Structural Phase in a Porous Construct
Linn W Thrane1,2, Emily A Berglund1, James N Wilking1
1Department of Chemical and Biological Engineering , Montana State University , Bozeman , Montana 59717-3920 , United States.
Abstract:
Nuclear magnetic resonance (NMR) frequency spectra and T2 relaxation time measurements, using a high-power radio frequency probe, are shown to characterize the presence of an amorphous drug in a porous silica construct. The results indicate the ability of non-solid-state NMR methods to characterize crystalline and amorphous solid structural phases in drugs. Two-dimensional T1- T2 magnetic relaxation time correlation experiments are shown to monitor the impact of relative humidity on the drug in a porous silica tablet.
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