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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Progression02:07

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Targeted Cancer Therapies02:57

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Updated: Jun 14, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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A "Counter-Enhancer" in Tumor Suppression.

Francesco P Marchese1, Maite Huarte1

  • 1University of Navarra, Center for Applied Medical Research (CIMA), Pamplona 31008, Spain; Institute of Health Research of Navarra (IdiSNA), Pamplona 31008, Spain.

Cell
|June 2, 2018
PubMed
Summary
This summary is machine-generated.

Researchers discovered a novel mechanism regulating MYC gene expression. A DNA element within the PVT1 gene acts as a competitor to promoters and enhancers, suggesting it may function as a tumor suppressor.

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Area of Science:

  • Cancer Biology
  • Genomics
  • Molecular Biology

Background:

  • The noncoding genome's role in cancer is increasingly recognized.
  • MYC gene expression is critical in cancer development and progression.

Purpose of the Study:

  • To elucidate a novel regulatory mechanism for MYC expression.
  • To investigate the function of a specific DNA element within the PVT1 gene.

Main Methods:

  • Analysis of gene regulation.
  • Investigating promoter-enhancer interactions.
  • Functional studies of DNA elements.

Main Results:

  • A DNA element within the PVT1 gene regulates MYC expression.
  • This element functions as a promoter-enhancer competitor.
  • The element shows potential as a tumor suppressor.

Conclusions:

  • A novel mechanism for MYC regulation involving the PVT1 gene promoter sequence has been identified.
  • This regulatory element acts as a promoter-enhancer competitor.
  • The findings suggest a potential tumor suppressor role for this DNA element.