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Implementing precision cancer medicine in the genomic era
Hui-Zi Chen1, Russell Bonneville2, Sameek Roychowdhury3
1Department of Internal Medicine, Division of Medical Oncology, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, United States; Department of Internal Medicine, Divisions of Medical Oncology and Hematology, Hematology and Oncology Fellowship Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, United States.
Seminars in Cancer Biology
|June 2, 2018
Summary
Precision oncology uses genomic data to match cancer patients with targeted therapies, aiming for better outcomes and fewer side effects. This approach guides complex cancer care through genomic alterations and clinical trials.
Area of Science:
- Oncology
- Genomics
- Molecular Biology
Background:
- Precision oncology utilizes genomic data to guide cancer treatment decisions.
- This approach matches patients to therapies based on tumor genetic drivers, not just histology.
- Expected benefits include improved response rates and reduced side effects.
Purpose of the Study:
- To review the utilization of genomic data in cancer patient care.
- To discuss actionable genomic alterations and diagnostic assay development.
- To provide an overview of genomics-driven clinical trials and future challenges.
Main Methods:
- Literature review of precision oncology principles and applications.
- Discussion of genomic alteration identification and diagnostic assay development.
- Overview of current genomics-driven clinical trials and implementation challenges.
Main Results:
- Genomic data is central to personalized cancer treatment strategies.
- A growing number of actionable genomic alterations are identified.
- Novel molecular diagnostic assays are being developed for clinical use.
- Genomics-driven clinical trials are expanding.
Conclusions:
- Precision oncology offers a paradigm shift in cancer care.
- Continued research and development are crucial for advancing personalized therapies.
- Addressing implementation challenges is key to realizing the full potential of precision oncology.
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