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Updated: Dec 28, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Evolution, kidney development, and chronic kidney disease.

Robert L Chevalier¹

¹Department of Pediatrics, The University of Virginia, P.O. Box 800386, Charlottesville, VA, United States.

Seminars in Cell & Developmental Biology

|June 2, 2018

Summary

This summary is machine-generated.

Chronic kidney disease (CKD) involves progressive nephron loss, driven by hypertension and diabetes. Evolutionary medicine offers new insights into understanding and treating CKD by examining nephron development and fate.

Keywords:

Chronic kidney disease Development Epigenetics Evolution Genetics Physiology

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Last Updated: Dec 28, 2025

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Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

Area of Science:

Nephrology
Evolutionary Medicine
Developmental Biology

Background:

Global epidemic of chronic kidney disease (CKD) characterized by progressive nephron loss.
Rising incidence of hypertension, metabolic syndrome, and type 2 diabetes mellitus contribute to CKD.
Significant variation in nephron number exists, with a natural decrease over a lifetime.

Purpose of the Study:

To provide a framework for understanding developmental nephrology and evolutionary biology.
To explore the integration of evolutionary medicine principles into CKD research.
To highlight the potential of evolutionary approaches in addressing CKD.

Main Methods:

Review of advances in kidney physiology, genetics, and development.
Integration of principles from evolutionary developmental biology (evo-devo), ecological developmental biology (eco-devo), and developmental origins of health and disease (DOHaD).
Examination of the role of environmental stressors and epigenetic regulation.

Main Results:

Elucidation of nephron formation, structure, and function through scientific advances.
Emergence of evolutionary medicine providing new investigative approaches for chronic diseases.
Establishment of evo-devo, eco-devo, and DOHaD frameworks.

Conclusions:

Evolutionary medicine offers promising new insights for treating chronic kidney disease.
Developmental nephrology, incorporating evolutionary principles, can address key questions about nephron fate.
This integrated approach positions developmental nephrology to tackle the complexities of CKD from development through senescence.