Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

10.9K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
10.9K
Complementation Tests00:49

Complementation Tests

6.3K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.3K
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.4K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.4K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

905
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
905
Overview of Transposition and Recombination02:13

Overview of Transposition and Recombination

19.4K
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
19.4K
Humoral Immune Responses01:36

Humoral Immune Responses

84.1K
Overview
84.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decreased bone mineral density in adults with type 2 intestinal failure: A descriptive cross-sectional study.

JPEN. Journal of parenteral and enteral nutrition·2026
Same author

Dysregulation of complement at the synapse in P301S mice and human tauopathies.

Acta neuropathologica communications·2026
Same author

Severe intraoperative hypertensive crisis during surgery for phaeochromocytoma/paraganglioma: analysis of pre-operative risk factors.

Gland surgery·2026
Same author

A synonymous SLC2A1 variant causes familial epilepsy and paroxysmal exercise-induced dyskinesia by creating aberrant mosaic splicing patterns.

Neurobiology of disease·2026
Same author

Loss of Response to Anti-Tumor Necrosis Factor Alpha Therapy in Patients With Inflammatory Bowel Disease: A Real-World Comparison of Combination Therapy Versus Monotherapy.

JGH open : an open access journal of gastroenterology and hepatology·2026
Same author

Sepsis severity in chronic intestinal failure patients presenting with catheter related blood stream infection.

Intestinal Failure (New York, N.Y.)·2026
Same journal

UNC13A-related neurodevelopmental disorders in children: epilepsy phenotypes and antiseizure medication response.

Seizure·2026
Same journal

Switching from oxcarbazepine to eslicarbazepine in patients with focal epilepsy: A systematic review and single-arm meta-analysis.

Seizure·2026
Same journal

Efficacy, tolerability, and EEG lateralization-based predictors of neuropsychiatric adverse events in pediatric SeLECTS treated with perampanel monotherapy.

Seizure·2026
Same journal

Cross-cultural validation of the International Classification of Cognitive Disorders in Epilepsy (IC-CoDE) in Chinese-speaking people with epilepsy.

Seizure·2026
Same journal

Unlocking seizure freedom: A European Delphi panel study on the clinical, humanistic, and economic value of seizure control in epilepsy.

Seizure·2026
Same journal

RLIM variant associated with X-linked epilepsy with neurodevelopmental disorders and the molecular sub-regional effects.

Seizure·2026
See all related articles

Related Experiment Video

Updated: Feb 9, 2026

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

21.2K

Complement system biomarkers in epilepsy.

Maja Kopczynska1, Wioleta M Zelek1, Simone Vespa1

  • 1Systems Immunity Research Institute and Division of Psychological Medicine and Clinical Neurology, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.

Seizure
|June 2, 2018
PubMed
Summary
This summary is machine-generated.

Complement dysregulation is implicated in epilepsy. This study suggests complement biomarkers may indicate disease severity and seizure control, warranting further investigation in larger patient cohorts.

Keywords:
BiomarkersEpilepsyInflammationPlasmaPredictorsSeizures

More Related Videos

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring
11:28

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring

Published on: June 13, 2025

1.3K
A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
09:41

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

12.7K

Related Experiment Videos

Last Updated: Feb 9, 2026

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

21.2K
Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring
11:28

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring

Published on: June 13, 2025

1.3K
A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
09:41

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

12.7K

Area of Science:

  • Neuroimmunology
  • Biomarker Discovery
  • Complement System Research

Background:

  • Epilepsy is a complex neurological disorder with increasing evidence suggesting immune system involvement.
  • The complement system, a crucial part of innate immunity, has been investigated for its potential role in various neurological conditions.

Purpose of the Study:

  • To investigate complement dysregulation in a clinical cohort of epilepsy patients.
  • To assess the potential of complement biomarkers for indicating epilepsy disease severity and seizure control.

Main Methods:

  • Plasma samples from 157 epilepsy patients and 54 controls were analyzed using enzyme-linked immunosorbent assay (ELISA).
  • Concentrations of 10 complement analytes and C-reactive protein (CRP) were measured.
  • Statistical analyses explored the predictive value of complement analytes for epilepsy diagnosis and seizure occurrence, and their correlation with anti-epileptic drug treatments.

Main Results:

  • The study identified specific complement analyte patterns in epilepsy patients.
  • While specific findings are not detailed in the abstract, the results contribute to evidence implicating complement in epilepsy pathogenesis.

Conclusions:

  • This research supports the role of the complement system in the underlying mechanisms of epilepsy.
  • Complement biomarkers show promise for future development of improved therapeutics and prognostic markers for epilepsy.
  • Further validation in larger patient cohorts is necessary to confirm these findings.