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Archimedes' principle is fundamental in analyzing the buoyant force and stability of floating bodies. In this example, a wooden block with a rectangular section floats in seawater. Based on the block's dimensions, its specific gravity and the specific weight of seawater are used to find the volume of water displaced and the center of buoyancy.
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Inertial Frames of Reference01:03

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Newton’s first law is usually considered to be a statement about reference frames. It provides a method for identifying a special type of reference frame: the inertial reference frame. In principle, we can make the net force on a body zero. If its velocity relative to a given frame is constant, then that frame is said to be inertial. So, by definition, an inertial reference frame is a reference frame where Newton's first law holds valid. Newton's first law applies to objects with...
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The Uncertainty Principle04:08

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Werner Heisenberg considered the limits of how accurately one can measure properties of an electron or other microscopic particles. He determined that there is a fundamental limit to how accurately one can measure both a particle’s position and its momentum simultaneously. The more accurate the measurement of the momentum of a particle is known, the less accurate the position at that time is known and vice versa. This is what is now called the Heisenberg uncertainty principle. He...
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Development of New Therapeutic Applications Using Microfluidics
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Progress of Inertial Microfluidics in Principle and Application.

Yixing Gou1, Yixuan Jia2, Peng Wang3

  • 1State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin 300072, China. gouyx@tju.edu.cn.

Sensors (Basel, Switzerland)
|June 3, 2018
PubMed
Summary
This summary is machine-generated.

Inertial microfluidics offers efficient particle manipulation without external fields. This review covers theoretical advances, force analyses, and applications in bioanalysis, highlighting its future role in integrated biochips.

Keywords:
Dean vortexinertial microfluidicslab-on-a-chipparticle manipulation

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Area of Science:

  • Microfluidics
  • Biotechnology
  • Biophysics

Background:

  • Inertial microfluidics is a popular research area due to its particle manipulation capabilities, simple structure, high throughput, and lack of external field requirements.
  • The flow regime in inertial microfluidics, while considered laminar, exhibits complex mechanical effects distinct from traditional microfluidic devices, complicating particle motion analysis.

Purpose of the Study:

  • To review the latest theoretical achievements and force analyses in inertial microfluidics.
  • To summarize the development process and applications of inertial microfluidics.
  • To discuss the future prospects of inertial microfluidics in integrated biochips and biomolecule analysis.

Main Methods:

  • Theoretical exploration of inertial migration effects in straight and curved channels.
  • Experimental investigation of particle manipulation using inertial microfluidics.
  • Review of existing literature on inertial microfluidics theory, force analysis, and applications.

Main Results:

  • Inertial migration effects in channels enable on-chip particle manipulation.
  • Applications span from basic particle handling to complex biochemical analysis.
  • Inertial microfluidics demonstrates significant potential for manipulating biological particles like circulating tumor cells, exosomes, and DNA.

Conclusions:

  • Inertial microfluidics provides unique advantages for particle manipulation.
  • Its role in integrated biochips and biomolecule analysis is expected to grow.
  • Further development will enhance its impact on various biological and analytical applications.