Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nuclear Stability03:18

Nuclear Stability

23.3K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
23.3K
RNA Stability01:53

RNA Stability

35.8K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.8K
Stability01:28

Stability

423
The time response of a linear time-invariant (LTI) system can be divided into transient and steady-state responses. The transient response represents the system's initial reaction to a change in input and diminishes to zero over time. In contrast, the steady-state response is the behavior that persists after the transient effects have faded.
The stability of an LTI system is determined by the roots of its characteristic equation, known as poles. A system is stable if it produces a bounded...
423
Protein Complex Assembly02:41

Protein Complex Assembly

16.8K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.8K
Stability of structures01:14

Stability of structures

532
In mechanical engineering, the stability of systems under various forces is critical for designing durable and efficient structures. One fundamental way to explore these concepts is by analyzing systems like two rods connected at a pivot point, O, with a torsional spring of spring constant k at the pivot point. This system is similar in appearance to a scissor jack used to change tires on a car. In this case, the arms of the linkage (equivalent to the rods in this system) are entirely vertical,...
532
Pole and System Stability01:24

Pole and System Stability

993
The transfer function is a fundamental concept representing the ratio of two polynomials. The numerator and denominator encapsulate the system's dynamics. The zeros and poles of this transfer function are critical in determining the system's behavior and stability.
Simple poles are unique roots of the denominator polynomial. Each simple pole corresponds to a distinct solution to the system's characteristic equation, typically resulting in exponential decay terms in the system's...
993

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Applying Distinct CDMS Strategies to Observe Nonclassical Virus Capsid Assembly.

Journal of mass spectrometry : JMS·2026
Same author

Native mass spectrometry meets X-rays for the elucidation of protein structures.

Biochemical Society transactions·2026
Same author

Statistical crystallography reveals an allosteric network in SARS-CoV-2 M<sup>pro</sup>.

Communications biology·2026
Same author

Automated high-throughput selection of DNA aptamers using a common optical next-generation sequencer.

Nucleic acids research·2026
Same author

The long and short of it: Distinct natural crystal packing strategies of Cry toxins from Bacillus thuringiensis.

Structure (London, England : 1993)·2026
Same author

Proteoform-Resolved Phosphorylation Dynamics in Kinase Complexes by Hybrid Precision Mass Spectrometry.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Feb 9, 2026

Plaque Assay for Murine Norovirus
10:53

Plaque Assay for Murine Norovirus

Published on: August 22, 2012

55.8K

Norovirus assembly and stability.

Ronja Pogan1, Jasmin Dülfer1, Charlotte Uetrecht2

  • 1Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.

Current Opinion in Virology
|June 3, 2018
PubMed
Summary

Noroviruses, a leading cause of gastroenteritis, show varied stability critical for environmental persistence. Understanding these differences in norovirus-like particles aids in distinguishing variants and studying viral emergence.

More Related Videos

Swab Sampling Method for the Detection of Human Norovirus on Surfaces
10:03

Swab Sampling Method for the Detection of Human Norovirus on Surfaces

Published on: February 6, 2017

20.3K
Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

10.2K

Related Experiment Videos

Last Updated: Feb 9, 2026

Plaque Assay for Murine Norovirus
10:53

Plaque Assay for Murine Norovirus

Published on: August 22, 2012

55.8K
Swab Sampling Method for the Detection of Human Norovirus on Surfaces
10:03

Swab Sampling Method for the Detection of Human Norovirus on Surfaces

Published on: February 6, 2017

20.3K
Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

10.2K

Area of Science:

  • Virology
  • Molecular Biology
  • Public Health

Background:

  • Noroviruses are rapidly evolving RNA viruses responsible for widespread viral gastroenteritis.
  • Particle stability is crucial for norovirus transmission via the fecal-oral route and environmental persistence.
  • Norovirus-like particles are essential tools for studying capsid assembly and disassembly.

Purpose of the Study:

  • To investigate the distinct stability patterns and assembly mechanisms of various human, murine, and bovine norovirus variants.
  • To deepen the understanding of norovirus emergence by analyzing differences and commonalities in particle stability.
  • To explore the potential for using stability characteristics to distinguish between different norovirus variants.

Main Methods:

  • Utilized norovirus-like particles to study capsid assembly and disassembly.
  • Investigated the stability of multiple human, murine, and bovine norovirus variants.
  • Analyzed distinct patterns of stability, assembly mechanisms, and intermediates across variants.

Main Results:

  • Identified distinct patterns of particle stability among different norovirus variants (human, murine, bovine).
  • Observed unique assembly mechanisms and intermediates associated with specific norovirus variants.
  • Highlighted significant differences and common features in the stability and assembly of noroviruses.

Conclusions:

  • Comparative analysis of norovirus-like particle stability reveals variant-specific characteristics.
  • Understanding these stability differences is key to comprehending norovirus emergence and evolution.
  • Standardized studies are needed to further elucidate norovirus stability and assembly for variant differentiation.