Related Experiment Video
Updated: Feb 9, 2026

Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c
Published on: June 29, 2011
Cytochrome c takes on plasmalogen catabolism
1From the Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 goldfinh@pennmedicine.upenn.edu.
Abstract:
Plasmalogens-phospholipids containing a characteristic vinyl ether group-are precursors of lipids important for cellular signaling such as arachidonic acid. Plasmalogen catabolism involves cleavage of the vinyl ether bond, but the identity of the corresponding enzyme that cleaves the sn-1 vinyl ether bond was unknown. New research shows that cytochrome c, with some help from another lipid, catalyzes the oxidative cleavage of this bond. This discovery, and the subsequent mechanistic dissection, provides exciting new directions for lipid signaling research.
More Related Videos
11:06Encapsulating Cytochrome c in Silica Aerogel Nanoarchitectures without Metal Nanoparticles while Retaining Gas-phase Bioactivity
Published on: March 1, 2016
06:53Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry
Published on: November 23, 2011
Related Concept Videos
Lipid Catabolism
Carbohydrate Catabolism
Amino Acid Catabolism
Types of Chemical Reactions: Anabolic and Catabolic
Anabolism is the process of combining smaller, simpler molecules into larger, more...
What is Metabolism?
Dietary Connections