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Risk of incident benign prostatic hyperplasia in patients with gout: a retrospective cohort study

Wei-Ming Li1,2,3, Nelly Pasaribu4, Su-Shin Lee5,6

  • 1Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Prostate Cancer and Prostatic Diseases
|June 3, 2018
PubMed

Insights

Gout increases the risk of benign prostatic hyperplasia (BPH) in men, especially younger individuals and those with gouty nephropathy. This association highlights a significant link between these two conditions.

Area of Science:

  • Urology
  • Rheumatology
  • Epidemiology

Background:

  • Gout, a common inflammatory arthritis, is associated with various comorbidities.
  • Benign prostatic hyperplasia (BPH) is a prevalent condition affecting aging men.
  • Understanding the relationship between gout and BPH is crucial for patient management.

Purpose of the Study:

  • To investigate the association between gout and the subsequent risk of developing benign prostatic hyperplasia (BPH).
  • To explore how age and specific gout phenotypes modify this association.

Main Methods:

  • Retrospective cohort study utilizing Taiwan's National Health Insurance Research Database.
  • Inclusion of 29,269 patients with gout and 29,269 matched controls (1:1 ratio) from 1997-2010.
  • Cox proportional hazards model used to assess the association, adjusting for potential confounders.

Main Results:

  • Patients with gout exhibited a higher incidence rate of BPH (19.62 vs. 10.11 per 1000 person-years).
  • Gout was associated with a 30% increased risk of BPH (adjusted HR 1.30; 95% CI 1.24-1.36).
  • The association was significantly stronger in younger age groups (20-40 years: HR 2.74; 41-60 years: HR 1.39) and in patients with gouty nephropathy (HR 1.30).

Conclusions:

  • Male gout is positively associated with an increased risk of benign prostatic hyperplasia.
  • This risk is particularly elevated in younger men with gout and those with gouty nephropathy.
  • Findings suggest a potential shared pathophysiology or common risk factors between gout and BPH.
Abstract

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