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Updated: Feb 9, 2026

Orthotopic Mouse Model of Colorectal Cancer
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Eicosanoid signaling in carcinogenesis of colorectal cancer

Yuxin Wang1,2, Weicang Wang2, Katherine Z Sanidad2,3

  • 1College of Life Science, Northwest University, Xi'an, Shaanxi, China.

Cancer Metastasis Reviews
|June 3, 2018
PubMed

Insights

Colorectal cancer (CRC) involves deregulated eicosanoid signaling. This review explores how cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) pathways impact CRC development, identifying potential therapeutic targets.

Area of Science:

  • Biochemistry
  • Oncology
  • Molecular Biology

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer death.
  • Identifying novel therapeutic targets and biomarkers for CRC is crucial.
  • Eicosanoids, lipid signaling molecules, are implicated in inflammation and tumorigenesis.

Purpose of the Study:

  • To review the roles of eicosanoid-producing enzymes in colorectal cancer.
  • To discuss the involvement of cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) pathways in CRC carcinogenesis.
  • To highlight potential therapeutic targets within eicosanoid signaling pathways.

Main Methods:

  • Literature review of studies on eicosanoids and CRC.
  • Analysis of the roles of COX, LOX, and CYP enzymes in colon cancer development.
  • Synthesis of current knowledge on eicosanoid signaling in CRC.

Main Results:

  • Eicosanoid profiles are frequently altered in CRC.
  • Enzymes, metabolites, and receptors in eicosanoid pathways are critical for colon tumorigenesis.
  • COX, LOX, and CYP pathways significantly influence CRC development.

Conclusions:

  • The eicosanoid signaling cascade is a key regulator of colonic inflammation and CRC.
  • Understanding the roles of COX, LOX, and CYP pathways offers opportunities for novel CRC therapies.
  • Targeting eicosanoid pathways may lead to new strategies for CRC prevention and treatment.
Keywords:
Colonic inflammationColorectal cancerCyclooxygenaseCytochrome P450EicosanoidsLipoxygenaseObesitySoluble epoxide hydrolase

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