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Updated: Feb 9, 2026

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles
Published on: June 28, 2021
[Synthesis and antitumor activity of cinnamoyloxy phosphonate derivatives]
Abstract:
In search of more effective anticancer agents, twelve compounds were designed and synthesized via microwave-assisted reactions of cinnamoyl chloride with α-hydroxyphosphonate. The structures of all the compounds were confirmed by IR, NMR and elemental analysis. Bioassay of the compounds were tested. They exhibited certain antitumor activities. Especially, compound 3c had obvious inhibitory effect on growth of SGC-7901 cells in vitro at 20 μmol·L(-1), and compound 3h showed better inhibitory effect on growth of SGC-7901 cells in vitro at 5 μmol·L(-1), the inhibition ratio were 68.8% and 48.0%, respectively.
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