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Compromised dynamic cerebral autoregulation in patients with generalized anxiety disorder: a study using transfer
Zhen-Ni Guo1,2, Shan Lv1, Jia Liu3
1Department of Neurology, The First Hospital of Jilin University, Xinmin Street 71#, Chang Chun, 130021, China.
BMC Psychiatry
|June 3, 2018
Summary
Generalized anxiety disorder (GAD) is linked to impaired dynamic cerebral autoregulation (dCA). Lower dCA function correlates with higher anxiety and depression scores, suggesting dCA as a potential therapeutic target.
Area of Science:
- Neuroscience
- Medical Psychology
Background:
- Generalized anxiety disorder (GAD) often involves neurological symptoms with unclear underlying mechanisms.
- Dynamic cerebral autoregulation (dCA) plays a crucial role in maintaining stable brain blood flow.
Purpose of the Study:
- To investigate the characteristics of dCA in patients diagnosed with GAD.
- To explore the relationship between dCA parameters and anxiety/depression symptom severity.
Main Methods:
- Study included 57 GAD patients and 40 healthy controls (age ≥18).
- Evaluated anxiety and depression using Hamilton scales (HAMA, HAMD).
- Measured continuous arterial blood pressure and middle cerebral artery blood flow velocity, analyzed using transfer function analysis for dCA parameters (phase difference, gain, coherence).
Main Results:
- Patients with GAD exhibited significantly compromised phase difference values compared to controls.
- Phase difference was negatively correlated with HAMA and HAMD scores.
- Multiple regression analysis indicated GAD negatively correlates with phase difference, while age positively correlates.
Conclusions:
- Dynamic cerebral autoregulation is impaired in GAD patients.
- Compromised dCA is associated with higher anxiety symptom severity.
- Enhancing dCA function may offer a novel therapeutic strategy for neurological symptoms in GAD.
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