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Subretinal drusenoid deposits AKA pseudodrusen.
Richard F Spaide1, Sotaro Ooto2, Christine A Curcio3
1Vitreous Retina Macula Consultants of New York and LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, USA.
Survey of Ophthalmology
|June 3, 2018
Summary
Subretinal drusenoid deposits (SDDs), previously called pseudodrusen, are linked to advanced age-related macular degeneration. These deposits increase the risk of geographic atrophy and neovascularization, impacting vision.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Macular Degeneration
Background:
- Subretinal drusenoid deposits (SDDs), formerly pseudodrusen, are distinct from conventional drusen.
- SDDs appear bluish-white and are located internal to the retinal pigment epithelium.
- They are more prevalent in older individuals with thinner choroids.
Purpose of the Study:
- To detail the characteristics and clinical significance of SDDs.
- To explore the association between SDDs and various forms of late age-related macular degeneration (AMD).
- To highlight recent advances in understanding SDDs and their impact.
Main Methods:
- Biomicroscopy and color fundus photography for visual appearance.
- Optical coherence tomography (OCT) for characterizing deposit location and extent.
- Histologic evaluation to determine composition and subretinal space involvement.
- Analysis of associations with AMD progression and visual function.
Main Results:
- SDDs are subretinal accumulations differing from soft drusen in lipid composition.
- SDDs are significant independent risk factors for geographic atrophy and type 3 neovascularization.
- Eyes with SDDs exhibit impaired dark adaptation and contrast sensitivity.
- Regression of SDDs can lead to outer retinal atrophy, a recognized form of late AMD.
Conclusions:
- SDDs represent a distinct entity with significant implications for AMD progression.
- Advanced imaging has improved the understanding of SDDs and associated retinal and choroidal changes.
- Early identification and monitoring of SDDs are crucial for managing patients at risk of advanced AMD.
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