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Computational morphogenesis - Embryogenesis, cancer research and digital pathology

Pridi Siregar1, Nathalie Julen1, Peter Hufnagl2

  • 1Integrative BioComputing - IBC, Chantepie, France.

Bio Systems
|June 4, 2018
PubMed

Insights

Computational morphogenesis (CM) offers new insights into cancer research by linking developmental processes to carcinogenesis. This approach, supported by digital pathology (DP), aids in understanding and diagnosing cancer more effectively.

Area of Science:

  • Integrative biology and computational modeling.
  • Cancer biology and developmental origins of cancer.
  • Digital pathology and machine learning applications.

Background:

  • Current cancer therapies often yield survival benefits below expectations.
  • Carcinogenesis shares mechanistic parallels with embryogenesis and tissue homeostasis.
  • Limitations in current cancer research necessitate novel approaches.

Purpose of the Study:

  • To explore the benefits of computational morphogenesis (CM) in cancer research.
  • To highlight the synergy between CM and digital pathology (DP).
  • To demonstrate how CM can enhance cancer diagnosis and understanding.

Main Methods:

  • Examining parallels between embryogenesis and carcinogenesis.
  • Utilizing computational morphogenesis (CM) for modeling.
  • Leveraging digital pathology (DP) for data acquisition and validation.
  • Generating synthetic data using CM for machine learning.

Main Results:

  • CM provides a framework to understand cancer as a disruption of developmental processes.
  • DP serves as a crucial data source for CM model development and validation.
  • CM-generated synthetic data can train machine learning algorithms for automated diagnosis.

Conclusions:

  • Computational morphogenesis offers a promising avenue for advancing cancer research and therapy.
  • The integration of CM and DP can significantly improve diagnostic accuracy.
  • Understanding cancer through the lens of developmental biology is key to future breakthroughs.
Keywords:
Cancer researchCarcinogenesisComputational morphogenesis (CM)Digital pathology (DP)Embryogenesis

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