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Racial and Ethnic Differences in Presentation and Outcomes of Hepatocellular Carcinoma

Nicole E Rich1, Caitlin Hester2, Mobolaji Odewole1

  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Parkland Health and Hospital System, Dallas, Texas.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|June 4, 2018
PubMed

Insights

Racial and ethnic minorities face worse outcomes for hepatocellular carcinoma (HCC). Disparities in early tumor detection and access to curative treatment contribute to these differences in HCC survival.

Area of Science:

  • Hepatocellular Carcinoma (HCC) Research
  • Health Disparities
  • Oncology Outcomes

Background:

  • Racial and ethnic minorities exhibit higher mortality rates for hepatocellular carcinoma (HCC) compared to non-Hispanic whites.
  • Existing research lacks clarity on whether tumor characteristics or liver dysfunction explain these disparities.
  • This study aimed to investigate racial and ethnic variations in HCC presentation, treatment, and survival outcomes.

Purpose of the Study:

  • To characterize racial and ethnic differences in the presentation of hepatocellular carcinoma (HCC).
  • To analyze disparities in treatment receipt for HCC among different racial and ethnic groups.
  • To evaluate the impact of race and ethnicity on overall survival in HCC patients.

Main Methods:

  • Retrospective analysis of 1117 patients diagnosed with HCC between January 2008 and July 2017.
  • Utilized multivariable logistic regression and Cox proportional hazard models.
  • Identified factors associated with curative therapy receipt and overall survival.

Main Results:

  • Hispanic and black patients were less likely to be diagnosed with early-stage HCC compared to white patients.
  • Among those with early-stage HCC, Hispanic patients were significantly less likely to receive curative treatment.
  • Black and Hispanic patients experienced shorter median survival times, with black patients showing significantly higher mortality post-adjustment.

Conclusions:

  • Racial and ethnic disparities in HCC outcomes are linked to differences in early tumor detection and the utilization of curative treatments.
  • Addressing these disparities in early detection and treatment access is crucial for improving patient outcomes.
  • Intervention strategies targeting early diagnosis and treatment receipt can help reduce HCC outcome disparities.
Abstract

Keywords:
BlackDisparitiesEarly DetectionHispanicLiver Cancer

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