Related Experiment Video
Updated: Feb 9, 2026
08:11
Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
Published on: November 14, 2016
11.6K
Disease activity in progressive multiple sclerosis can be effectively reduced by cladribine
1The Blizard Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom; Clinical Board: Medicine (Neuroscience), The Royal London Hospital, Barts Health NHS Trust, London, United Kingdom.
Multiple Sclerosis and Related Disorders
|June 4, 2018
Summary
Disease-modifying therapy (DMT) may benefit people with progressive multiple sclerosis (pwPMS). Subcutaneous cladribine showed reduced neurofilament light chain (NfL) levels and disease activity in two pwPMS, suggesting cladribine as a potential treatment option.
Area of Science:
- Neuroimmunology
- Neurology
- Biomarker research
Background:
- People with progressive multiple sclerosis (pwPMS) may benefit from disease-modifying therapies (DMTs), but treatment options are limited.
- Assessing treatment outcomes in pwPMS is challenging, hindering DMT development.
- Cerebrospinal fluid (CSF) neurofilament light chain (NfL) and heavy chain (NfH) levels serve as biomarkers for neuro-axonal damage and potential treatment outcome indices.
Observation:
- Two pwPMS received subcutaneous cladribine treatment.
- CSF NfL levels, MRI, and clinical status were monitored before and after treatment.
- Cladribine treatment was well-tolerated with no reported side effects.
Findings:
- CSF NfL levels significantly decreased post-treatment (73% and 80% reduction).
- MRI scans indicated a reduction in disease activity.
- One patient experienced mild disability progression, while the other remained stable.
Implications:
- pwPMS with active disease (indicated by MRI and elevated NfL) may be candidates for DMT.
- NfL is a sensitive biomarker for treatment response in pwPMS and valuable for clinical trials.
- Cladribine may be an effective treatment for pwPMS beyond its approved indication for relapsing MS.
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