Related Experiment Video

Updated: Feb 9, 2026

Transcranial Direct Current Stimulation for Online Gamers
06:01

Transcranial Direct Current Stimulation for Online Gamers

Published on: November 9, 2019

8.6K

Breakthrough Invasive Mold Infections in the Hematology Patient: Current Concepts and Future Directions

Michail S Lionakis1, Russell E Lewis2, Dimitrios P Kontoyiannis3

  • 1Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|June 4, 2018
PubMed

Insights

Despite advances in antifungal therapies, breakthrough invasive mold infections (bIMIs) remain a challenge in patients with hematological malignancies and stem cell transplants. Managing bIMIs requires individualized treatment plans considering patient factors and fungal resistance.

Area of Science:

  • Clinical Mycology
  • Hematology
  • Infectious Diseases

Background:

  • Widespread use of mold-active agents has reduced invasive mold infections (IMIs) in hematological malignancy and HSCT patients.
  • A subset of these high-risk patients still develop breakthrough IMIs (bIMIs) despite antifungal prophylaxis.
  • Limited prospective randomized clinical trial data exist to guide bIMI treatment decisions.

Purpose of the Study:

  • To present the current understanding of clinical, diagnostic, and treatment challenges of bIMIs.
  • To outline common clinical scenarios for bIMIs in high-risk adult patients.
  • To highlight areas for future investigation in managing bIMIs.

Main Methods:

  • This is a viewpoint article, not a primary research study.
  • It synthesizes current knowledge on bIMIs based on existing literature and clinical experience.
  • Focuses on challenges in diagnosis and treatment strategies for bIMIs in immunocompromised hosts.

Main Results:

  • Breakthrough invasive mold infections (bIMIs) continue to occur in patients receiving mold-active antifungals.
  • Management of bIMIs is complex and requires an individualized approach.
  • Key factors influencing management include host status, diagnostic certainty, infection site, local epidemiology, and antifungal properties.

Conclusions:

  • Individualized treatment plans are crucial for managing bIMIs in high-risk hematology and HSCT patients.
  • Consideration of host factors, fungal resistance, and drug properties is essential.
  • Further research is needed to address the complexities of bIMI management.

More Related Videos

Home-Based Transcranial Direct Current Stimulation Device Development: An Updated Protocol Used at Home in Healthy Subjects and Fibromyalgia Patients11:26

Home-Based Transcranial Direct Current Stimulation Device Development: An Updated Protocol Used at Home in Healthy Subjects and Fibromyalgia Patients

Published on: July 14, 2018

18.0K
Simultaneous EEG Monitoring During Transcranial Direct Current Stimulation07:52

Simultaneous EEG Monitoring During Transcranial Direct Current Stimulation

Published on: June 17, 2013

40.4K

Related Concept Videos

Self-Concept01:19

Self-Concept

Self-concept is the cognitive and emotional understanding individuals hold about their identity. It evolves through various developmental stages, beginning in infancy and maturing as children grow. This concept influences how individuals perceive their abilities, interact with others, and manage challenges throughout life.
Infancy and Emerging Recognition
During infancy, self-concept is virtually nonexistent. Babies do not distinguish themselves as separate entities and often mistake their...
1.7K
Concepts and Prototypes01:24

Concepts and Prototypes

The human nervous system handles vast amounts of information by translating sensory stimuli into neural impulses, which the brain processes, creating thoughts expressed through language or stored as memories. The brain also synthesizes information from emotions and memories, which significantly influence thoughts and behaviors. This intricate process creates a comprehensive mental picture.
The brain organizes this information using concepts, which are mental categories grouping linguistic data,...
552
Formula Mass and Mole Concepts of Compounds02:56

Formula Mass and Mole Concepts of Compounds

Formula Mass of Covalent Compounds
81.9K
Concept of Pressure at a Point01:15

Concept of Pressure at a Point

The concept of pressure at a point in a fluid establishes that pressure within a fluid is uniform in all directions at a specific location. This uniformity occurs because fluid molecules exert force evenly across any point due to their random motion and continuous collisions within the fluid. Pressure at a point is determined by the surrounding fluid molecules and is influenced by factors like depth and density, rather than by shape or orientation.
In a fluid at rest, pressure acts equally in...
783
Understanding Self-Concept01:20

Understanding Self-Concept

The self-concept encompasses individuals' beliefs about themselves, structured through cognitive frameworks known as self-schemas. These schemas function as mental representations of specific traits or behaviors, influencing how self-relevant information is perceived, processed, and remembered. For example, individuals who are schematic for body weight are more likely to interpret routine experiences—such as dining out or shopping—through the lens of that trait. Conversely, those...
298
Basic Concept01:28

Basic Concept

Engineering mechanics is a branch of engineering that studies motion and the forces acting on objects. It is a fundamental subject and forms the basis of many other engineering disciplines. Length, time, mass, and force are some basic concepts in engineering mechanics.
Length, which measures the distance traveled by an object, is a fundamental concept in engineering mechanics. We use coordinates relative to a reference point to describe the distance. Length not only helps to describe the...
6.2K