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Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium
Britton Trabert1, Elizabeth M Poole2, Emily White3,4
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Journal of the National Cancer Institute
|June 4, 2018
Summary
Daily aspirin use is linked to a 10% reduced risk of ovarian cancer, according to a large prospective study. However, long-term frequent use of aspirin or NSAIDs may slightly increase risk, warranting further investigation.
Area of Science:
- Oncology
- Epidemiology
- Pharmacology
Background:
- Aspirin use is associated with reduced risk for several cancers.
- Previous pooled analysis indicated a 10% decrease in ovarian cancer risk with regular aspirin use.
- This study aimed to prospectively investigate analgesic use and ovarian cancer risk.
Purpose of the Study:
- To prospectively investigate the association between analgesic use and ovarian cancer risk.
- To evaluate the impact of aspirin, nonaspirin NSAIDs, and acetaminophen on ovarian cancer risk.
- To assess the influence of dose and duration of analgesic use on ovarian cancer risk.
Main Methods:
- Analysis of data from 13 studies within the Ovarian Cancer Cohort Consortium (OC3).
- Inclusion of 758,829 women, with 3514 developing ovarian cancer.
- Use of Cox regression to assess associations between frequent medication use and ovarian cancer risk, including dose and duration.
Main Results:
- Almost daily aspirin use (≥6 days/wk) was associated with a 10% reduction in ovarian cancer risk (RR=0.90).
- Frequent use of aspirin, nonaspirin NSAIDs, or acetaminophen was not significantly associated with ovarian cancer risk.
- Daily acetaminophen use was linked to an elevated ovarian cancer risk (RR=1.28).
- Frequent, long-term aspirin or nonaspirin NSAID use showed a modest, non-significant elevation in risk.
Conclusions:
- Daily aspirin use is associated with a modest reduction in ovarian cancer risk.
- Potential elevated risks for long-term frequent aspirin and NSAID use require further investigation.
- Confounding factors or variations in drug dosing may explain potential elevated risks.
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