Related Experiment Video
Updated: Aug 19, 2026

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
Published on: May 15, 2021
Cis-platinum and distal renal tubule toxicity
Abstract:
Glomerular filtration rate (GFR) and plasma electrolyte concentrations were evaluated prospectively in 22 consecutive patients treated with serial courses of cisplatinum combination chemotherapy. In addition, renal distal tubular function was assessed in the first 12 by measurement of overnight urinary concentration after intranasal desamino-d-arginine vasopressin inhalation and by a standard short urinary acidification test following the administration of oral ammonium chloride. Cumulative and dose-related hypomagnesaemia was observed in all patients but was unassociated with clinical symptoms. No significant fall in GFR was seen in the group as a whole but four of the 12 patients studied more comprehensively developed impairment of urinary concentrating and acidifying abilities, independent of any change in GFR. This indicates a selective effect on the renal distal tubule.
Related Concept Videos
Drug Elimination by Renal Route: Tubular Reabsorption
Renal Tubule and Collecting Duct
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Renal Drug Excretion: Tubular Reabsorption
Renal Drug Excretion: Tubular Secretion
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Acute Kidney Injury IV: Diagnostic Studies and Prevention

