Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antibiotic Selection00:57

Antibiotic Selection

60.1K
Overview
60.1K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.5K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.5K
Continuing Care01:25

Continuing Care

2.0K
Continuing care describes the variety of health, personal, and social services provided over a prolonged period. The need for continuing care is increasing because people are living longer. Many people do not have families or others to care for them. Continuing care is mainly for patients who are disabled, functionally dependent, or suffering from a terminal disease. It is available within institutional settings or in homes. Examples include nursing centers or facilities, assisted living,...
2.0K
Continuity of a Function01:23

Continuity of a Function

250
A function is continuous at a point a if three conditions are met: the function is defined at a, the limit of the function as x approaches a exists, and this limit equals the function’s value. Mathematically, this is written asThis definition ensures the graph of the function does not exhibit any breaks, holes, or jumps at that point. Discontinuities occur when any of these conditions fail. A removable discontinuity exists when the two-sided limit exists but the function is either...
250
Continuity Equation01:28

Continuity Equation

3.3K
The continuity equation asserts that the mass flow rate must remain constant for a steady flow of an incompressible fluid within a confined system. This principle applies to systems where fluid passes through varying cross-sectional areas, such as nozzles, syringes, and pipes.
The mass flow rate is expressed as:
3.3K
Continuity Equation01:20

Continuity Equation

1.5K
The total amount of current flowing per unit cross-sectional area is called the current density. Hence, the current passing through a cross-sectional area can be written as the surface integral of the current density.
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic criteria for invasive pulmonary aspergillosis in COPD patients.

American journal of respiratory and critical care medicine·2026
Same author

Collagen- and elastin-derived biomarkers and acute severe exacerbations in COPD: a sub study of the CORTICO-COP trial.

Scientific reports·2026
Same author

From surveillance to participation: redefining respiratory virus epidemiology in the era of self-testing.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2026
Same author

Withdrawal effects following treatment discontinuation: A blind spot in evidence-based medicine.

Med (New York, N.Y.)·2026
Same author

ERS statement: Core outcome set for trials evaluating the management of community-acquired and nosocomial pneumonia in adults.

The European respiratory journal·2026
Same author

COPD Trial Evidence Comes From a Narrow Slice of the World: A Population Representativeness Analysis.

Chest·2026
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles

Related Experiment Video

Updated: Feb 9, 2026

Author Spotlight: Accessible M&M-Based Mouse Model for Investigating Binge Eating Disorder - Insights into Eating Behaviors, Anxiety, and Neural Mechanisms
05:15

Author Spotlight: Accessible M&M-Based Mouse Model for Investigating Binge Eating Disorder - Insights into Eating Behaviors, Anxiety, and Neural Mechanisms

Published on: January 10, 2025

1.8K

Continuous versus intermittent antibiotics for bronchiectasis.

Tim Donovan1, Lambert M Felix, James D Chalmers

  • 1Medical and Sport Sciences, University of Cumbria, Lancaster, UK.

The Cochrane Database of Systematic Reviews
|June 4, 2018
PubMed
Summary
This summary is machine-generated.

This review found no studies comparing continuous versus intermittent antibiotics for bronchiectasis. More research is needed to determine the best antibiotic strategy for managing this chronic airway disease and preventing resistance.

More Related Videos

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.7K
Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
08:06

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

9.6K

Related Experiment Videos

Last Updated: Feb 9, 2026

Author Spotlight: Accessible M&M-Based Mouse Model for Investigating Binge Eating Disorder - Insights into Eating Behaviors, Anxiety, and Neural Mechanisms
05:15

Author Spotlight: Accessible M&M-Based Mouse Model for Investigating Binge Eating Disorder - Insights into Eating Behaviors, Anxiety, and Neural Mechanisms

Published on: January 10, 2025

1.8K
Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.7K
Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
08:06

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

9.6K

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Pharmacology

Background:

  • Bronchiectasis is a chronic airway disease characterized by recurrent infections, inflammation, and tissue damage.
  • Antibiotics are a primary treatment, with continuous or intermittent prophylactic strategies employed to manage bacterial load.
  • Concerns exist regarding antibiotic resistance with continuous therapy, while intermittent therapy may reduce selection pressure.

Purpose of the Study:

  • To systematically review evidence comparing continuous versus intermittent prophylactic antibiotic administration in bronchiectasis.
  • To evaluate clinical efficacy, emergence of antibiotic resistance, and serious adverse events.
  • To identify randomized controlled trials (RCTs) addressing this comparison.

Main Methods:

  • Searched multiple databases (Cochrane, MEDLINE, Embase, etc.) and trial registries up to May 2018.
  • Included RCTs of adults or children with bronchiectasis comparing long-term prophylactic antibiotic regimens (≥3 months).
  • Two reviewers independently screened records and full-text reports.

Main Results:

  • Identified 268 unique records, examining 126 full-text reports from 114 studies.
  • Crucially, no randomized controlled trials met the inclusion criteria for this review.
  • Therefore, no direct comparative data exists for continuous versus intermittent antibiotic therapy in bronchiectasis.

Conclusions:

  • There is a significant lack of high-quality evidence comparing continuous and intermittent antibiotic therapies for bronchiectasis.
  • Further well-designed clinical trials are essential to guide optimal antibiotic selection.
  • Such trials should focus on reducing exacerbations, preventing antibiotic resistance, and monitoring adverse events.