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Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
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Infratentorial Cerebral Microbleeds in Patients with Cerebral Amyloid Angiopathy

Dimitri Renard1, Lavinia Tatu1, Eric Thouvenot2

  • 1Department of Neurology, Nîmes University Hospital, Hôpital Caremeau, Nîmes, France.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|June 5, 2018
PubMed
Abstract

Insights

Superficial cerebellar microbleeds (CMBs) are linked to cerebral amyloid angiopathy (CAA), appearing in a minority of patients with high lobar CMB loads. Infratentorial CMBs in CAA are uncommon but show distinct associations.

Area of Science:

  • Neurology
  • Neuroradiology
  • Cerebrovascular Disease

Background:

  • Cerebral microbleeds (CMBs) distribution differs between hypertension and cerebral amyloid angiopathy (CAA).
  • CAA-related CMBs typically occur in the supratentorial lobar regions.
  • Infratentorial CMBs in CAA are understudied.

Purpose of the Study:

  • To investigate the incidence, number, and characteristics of infratentorial CMBs in patients with CAA.
  • To differentiate infratentorial CMB patterns in CAA.

Main Methods:

  • Retrospective analysis of prospectively recruited patients with possible or probable CAA (Boston criteria).

Main Results:

  • 18% of 115 CAA patients had infratentorial CMBs.
  • Superficial cerebellar CMBs (10%) associated with lobar CMBs; brainstem/deep cerebellar CMBs (8%/4%) associated with deep gray matter CMBs and hypertension.
  • Superficial cerebellar CMBs occurred in low numbers.

Conclusions:

  • Superficial cerebellar CMBs may represent a CAA-related phenomenon.
  • These CMBs are observed in a minority of CAA patients with high supratentorial lobar CMB burden.
  • Infratentorial CMB patterns may help differentiate underlying causes of CMBs in CAA.
Keywords:
Infratentorialbrainstemcerebellumcerebral amyloid angiopathycerebral microbleeds

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