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MicroRNA and Breast Cancer: Understanding Pathogenesis, Improving Management

Steven C Eastlack1, Suresh K Alahari2

  • 1Department of Biochemistry and Molecular Biology, LSU Health Science Center; 533 Bolivar Street, New Orleans, LA 70112, USA. seastl@lsuhsc.edu.

Non-Coding RNA
|June 5, 2018
PubMed

Insights

MicroRNAs (miRNAs) are key regulators of gene expression implicated in cancer. This review details their roles in breast cancer, from initiation to treatment, and highlights research challenges.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are crucial for gene regulation and cellular function.
  • Dysregulated miRNA expression is linked to cancer development and progression.

Purpose of the Study:

  • To provide a comprehensive overview of well-characterized miRNAs in human breast neoplasia.
  • To discuss the multifaceted roles of miRNAs in breast cancer pathogenesis and potential therapeutic applications.

Main Methods:

  • Literature review and synthesis of existing research on miRNAs in breast cancer.
  • Analysis of miRNA involvement in tumor initiation, progression, EMT, and cancer stem cells.

Main Results:

  • miRNAs play significant roles in tumor initiation, progression, epithelial-mesenchymal transition (EMT), and cancer stem cell formation.
  • miRNAs show potential as biomarkers in tissues and circulation and are being explored for cancer treatment.

Conclusions:

  • Understanding miRNA functions is vital for advancing breast cancer research and therapy.
  • Further research is needed to address underexplored areas like miRNA metabolism and resolve conflicting study findings.
Keywords:
breast cancercancer stem cellsmetastasismiRNAserum biomarker

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