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Sources of Self-Esteem II: Performance Feedback01:24

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Self-esteem is intricately tied to our perception of competence and our ability to exert control over our lives. One of the primary sources of this perception is performance feedback — the ongoing evaluation of our actions in terms of success and failure. According to Franks and Marolla (1976), people derive self-worth from experiencing themselves as causal agents, capable of achieving goals and overcoming obstacles. This process nurtures a critical component of self-esteem:...
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PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
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High-performance reoxygenation from PLGA-PEG/PFOB emulsions: a feedback relationship between ROS and HIF-1α.

Jie Wang1, Ruochen Wang1, Niannian Li1

  • 1School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

International Journal of Nanomedicine
|June 5, 2018
PubMed
Summary
This summary is machine-generated.

A new emulsion effectively supplies oxygen to alleviate hypoxemia, demonstrating low toxicity and improving cell viability by regulating reactive oxygen species and hypoxia-inducible factor-1α (HIF-1α). This novel approach shows promise for treating hypoxemic conditions.

Keywords:
hypoxia-inducible factor-1αhypoxia-reoxygenationlung ventilationoxygen concentrationperfluorocarbonreactive oxygen species

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Area of Science:

  • Biomaterials Science
  • Pulmonary Medicine
  • Cellular Physiology

Background:

  • Hypoxemia is a prevalent pathological process across diverse clinical conditions.
  • Effective oxygen delivery remains a critical challenge in managing hypoxemic diseases.

Purpose of the Study:

  • To develop and evaluate a novel poly(lactide-co-glycolide)-poly(ethylene glycol)/perfluorooctyl bromide emulsion for pulmonary oxygen delivery.
  • To assess the emulsion's efficacy in improving arterial hypoxemia and its impact on cellular responses.

Main Methods:

  • Development of a novel emulsion for pulmonary drug delivery.
  • In vitro hypoxia-reoxygenation experiments to assess oxygen supply capacity.
  • Establishment of a saline lavage acute lung injury model in rabbits to evaluate in vivo efficacy.

Main Results:

  • The emulsion exhibited low cytotoxicity, indicating good biocompatibility.
  • Adequate oxygen supply by the emulsion promoted cell growth and viability during reoxygenation.
  • The emulsion modulated intracellular reactive oxygen species and upregulated hypoxia-inducible factor-1α (HIF-1α), crucial for cell survival.
  • Significant improvement in lung ventilation was observed in rabbits with acute lung injury.

Conclusions:

  • The feedback loop between reactive oxygen species and HIF-1α is vital for enhancing cell viability.
  • The developed emulsion holds significant potential for clinical application in alleviating hypoxemia.