The Association Between Inflammatory Markers and Hypertension. A Call for Anti-Inflammatory Strategies?
Néstor H García1, Luis I Juncos1
1J. Robert Cade Foundation CONICET, Córdoba, Argentina.
Thescientificworldjournal
|June 5, 2018
Summary
Hypertension triggers inflammation, leading to endothelial dysfunction and organ damage. Anti-inflammatory treatments may prevent these complications, offering new therapeutic targets beyond blood pressure control.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Inflammation Research
Background:
- Antihypertensive therapy aims to prevent hypertension complications like stroke and renal disease.
- Secondary targets include left ventricular hypertrophy and proteinuria for risk assessment.
- Endothelial dysfunction is an emerging target, potentially preceding hypertension and contributing to comorbidities.
Purpose of the Study:
- To review research on hypertension-induced inflammation.
- To explore anti-inflammatory approaches for endothelial dysfunction.
- To assess the prevention of renal and cardiovascular damage.
Main Methods:
- Review of animal and human studies on hypertension and inflammation.
- Evaluation of anti-inflammatory agents and their effects.
- Analysis of renin-angiotensin-aldosterone system antagonists, statins, and beta blockers.
Main Results:
- Hypertension initiates an inflammatory state.
- Endothelial dysfunction may precede elevated blood pressure.
- Anti-inflammatory agents may delay proinflammatory molecule induction.
Conclusions:
- Endothelial dysfunction is a key factor in hypertension-related organ damage.
- Targeting inflammation offers a novel strategy for managing hypertension.
- Anti-inflammatory approaches may prevent cardiovascular and renal damage.
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