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Asymptomatic Leishmania Infected Children: A Seroprevalence and Molecular Survey in a Rural Area of Fars Province,

Akram Layegh Gigloo1, Bahador Sarkari1,2, Zahra Rezaei1,3

  • 1Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Journal of Tropical Medicine
|June 5, 2018
PubMed

Insights

A study in Iran found a significant rate of subclinical visceral leishmaniasis (VL) in healthy children. This highlights the need for better surveillance and control of VL in the region.

Area of Science:

  • Infectious Diseases
  • Parasitology
  • Epidemiology

Background:

  • Visceral leishmaniasis (VL) is a serious parasitic disease.
  • Subclinical infections are common but often overlooked.
  • Understanding seroprevalence in asymptomatic populations is crucial for control.

Purpose of the Study:

  • To determine the seroprevalence of visceral leishmaniasis in asymptomatic children.
  • To detect Leishmania infantum DNA in a rural area of Fars province, Iran.
  • To assess the association between seropositivity and demographic factors.

Main Methods:

  • Blood samples collected from 617 healthy children.
  • Indirect ELISA used to detect anti-Leishmania antibodies.
  • Molecular methods (PCR) used to detect L. infantum DNA in buffy coats.

Main Results:

  • Seroprevalence of anti-Leishmania antibodies was 2.8% (17/617).
  • L. infantum DNA detected in 1.3% (8/617) of children.
  • No significant association found between seropositivity and gender or age.

Conclusions:

  • A considerable burden of subclinical leishmaniasis exists in the studied population.
  • Findings support enhanced surveillance and control strategies for VL in Southern Iran.
  • The study underscores the importance of detecting asymptomatic carriers for effective disease management.

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