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Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery

Suzana Bojic1, Jelena Kotur-Stevuljevic2, Aleksandra Aleksic1

  • 1Department of Anaesthesiology and Intensive Care, CHC Bezanijska Kosa, 11000 Belgrade, Serbia.

Disease Markers
|June 5, 2018
PubMed
Abstract

Insights

Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) show promise as biomarkers for diagnosing and predicting sepsis after major abdominal surgery. These markers correlate with organ dysfunction and patient survival.

Area of Science:

  • Biochemistry
  • Surgical Oncology
  • Critical Care Medicine

Background:

  • The role of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in sepsis following major abdominal surgery remains unclear.
  • Sepsis-associated organ dysfunction requires better diagnostic and prognostic tools.

Purpose of the Study:

  • To investigate the diagnostic and prognostic value of MMP-9 and TIMP-1 in patients with sepsis after major abdominal surgery.
  • To explore the association between MMP-9/TIMP-1 ratios and sepsis-related organ dysfunction.

Main Methods:

  • A comparative study involving 53 septic patients, 50 operated controls, and 50 nonoperated controls.
  • Daily measurements of MMP-9, TIMP-1, inflammation biomarkers, and organ injury markers for 96 hours post-sepsis diagnosis.
  • Calculation of MMP-9/TIMP-1 ratios, disease severity scores, and recording of clinical outcomes including survival.

Main Results:

  • Septic patients exhibited lower MMP-9 and MMP-9/TIMP-1 ratios, and higher TIMP-1 levels compared to controls.
  • TIMP-1 and MMP-9/TIMP-1 ratio demonstrated high diagnostic accuracy for sepsis.
  • Lower MMP-9/TIMP-1 ratios and higher TIMP-1 levels were linked to poorer survival and correlated with inflammation, organ injury, and disease severity.

Conclusions:

  • MMP-9, TIMP-1, and their ratio are valuable diagnostic and prognostic biomarkers for sepsis post-major abdominal surgery.
  • These biomarkers are significantly associated with the severity of sepsis-associated organ dysfunction.

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