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Updated: Feb 9, 2026

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Published on: May 2, 2025
Pd(ii)-catalyzed remote regiodivergent ortho- and meta-C-H functionalizations of phenylethylamines
Shangda Li1, Huafang Ji1, Lei Cai1
1Key Laboratory of Coal to Ethylene Glycol and Its Related Technology , Fujian Institute of Research on the Structure of Matter , Chinese Academy of Sciences , 155 West Yang-Qiao Road , Fuzhou , Fujian 350002 , P. R. China .
Abstract:
Site selectivity control is of vital importance in the direct functionalization of inert C-H bonds. Reported here is a novel example of remote regiodivergent ortho- and meta-C-H bond functionalizations of phenylethylamine derivatives by using a novel 2-cyanobenzoyl group as the original directing functionality, where the regioselectivity was adjusted by a methylation. The potential of the method was exemplified by sequential functionalizations of both ortho- and meta-C-H bonds of a phenylethylamine derivative in a streamlined manner.
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