Fluoride responsive single nanochannel: click fabrication and highly selective sensing in aqueous solution

Area of Science:

• Analytical Chemistry
• Materials Science
• Biomedical Engineering

Background:

• Fluoride ions (F-) play critical roles in natural and biological processes.
• Accurate and selective detection of F- in aqueous environments is essential for various applications.
• Existing F- sensing methods may face challenges with selectivity and applicability in complex matrices.

Purpose of the Study:

• To develop a highly selective nanochannel-based sensor for F- detection in aqueous solutions.
• To utilize hydrogen-bonding interactions for specific F- recognition.
• To assess the sensor's performance in biological samples and its recyclability.

Main Methods:

• Fabrication of a nanochannel modified with 1,3-dipropargylaza-p-tert-butyl calix[4]crown (C4CE).
• Utilizing hydrogen-bonding interactions between the C4CE-modified nanochannel and F- ions.
• Testing the sensor's selectivity and performance in aqueous solutions and human serum.
• Evaluating the recyclability of the nanochannel sensor.

Main Results:

• The C4CE-modified nanochannel exhibited high selectivity for F- ions.
• The sensor demonstrated effective F- detection even in the complex matrix of human serum.
• The nanodevice proved to be recyclable, indicating its potential for repeated use.

Conclusions:

• The developed nanochannel sensor offers a promising approach for selective and sensitive F- detection.
• The sensor's ability to function in serum highlights its potential for biomedical applications.
• The recyclability of the device enhances its practicality and cost-effectiveness for F- sensing.