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Updated: Feb 9, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
The first chiral diene-based metal-organic frameworks for highly enantioselective carbon-carbon bond formation
Takahiro Sawano1, Pengfei Ji1, Alexandra R McIsaac1
1Department of Chemistry , University of Chicago , 929 E 57th St , Chicago , Illinois 60637 , USA .
Abstract:
We have designed the first chiral diene-based metal-organic framework (MOF), E2-MOF, and postsynthetically metalated E2-MOF with Rh(i) complexes to afford highly active and enantioselective single-site solid catalysts for C-C bond formation reactions. Treatment of E2-MOF with [RhCl(C2H4)2]2 led to a highly enantioselective catalyst for 1,4-additions of arylboronic acids to α,β-unsaturated ketones, whereas treatment of E2-MOF with Rh(acac)(C2H4)2 afforded a highly efficient catalyst for the asymmetric 1,2-additions of arylboronic acids to aldimines. Interestingly, E2-MOF·Rh(acac) showed higher activity and enantioselectivity than the homogeneous control catalyst, likely due to the formation of a true single-site catalyst in the MOF. E2-MOF·Rh(acac) was also successfully recycled and reused at least seven times without loss of yield and enantioselectivity.
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