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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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Breakthroughs in the treatment of advanced squamous-cell NSCLC: not the neglected sibling anymore?

Georgios Tsironis1, Dimitrios C Ziogas1, Anastasios Kyriazoglou1

  • 1Department of Clinical Therapeutics, Alexandra General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

Annals of Translational Medicine
|June 5, 2018
PubMed

Insights

Advances in non-small cell lung cancer (NSCLC) treatment have expanded options for squamous cell lung cancer (SqCLC). This review covers new therapies and ongoing trials for advanced SqCLC, focusing on personalized medicine.

Area of Science:

  • Oncology
  • Translational Research
  • Cancer Therapeutics

Background:

  • Non-small cell lung cancer (NSCLC) treatment has seen significant advances, particularly in non-squamous subtypes.
  • Therapeutic options for advanced squamous cell lung cancer (SqCLC) have also expanded.
  • Understanding of lung cancer's immuno-escape and neo-angiogenesis has driven progress.

Purpose of the Study:

  • To review recent therapeutic approvals for advanced squamous cell lung cancer (SqCLC).
  • To summarize ongoing clinical trials investigating new molecular targets for SqCLC.
  • To highlight the shift towards a personalized approach in SqCLC treatment.

Main Methods:

  • Review of published data on recent SqCLC treatment approvals.
  • Analysis of ongoing clinical trials for advanced SqCLC.
  • Synthesis of information on targeted therapies and immunotherapies.

Main Results:

  • Established therapies for advanced SqCLC include nab-paclitaxel, EGFR inhibitors (necitumumab, afatinib, erlotinib), and VEGF inhibitors (ramucirumab).
  • Immunotherapies such as nivolumab, pembrolizumab, atezolizumab, and durvalumab show promise.
  • Investigational agents target pathways like FGFR, IGF-1, PI3K, CDK4/6, MET, and PARP.

Conclusions:

  • Recent approvals have significantly enriched treatment options for advanced SqCLC.
  • Ongoing research focuses on novel molecular targets and personalized treatment strategies.
  • The future of SqCLC treatment lies in continued investigation of targeted agents and immunotherapies.
Keywords:
Non-small cell lung cancer (NSCLC)immunotherapysquamous cell lung cancer (SqCLC)targeted therapy

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