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Updated: Feb 9, 2026
09:46
Intracranial Implantation with Subsequent 3D In Vivo Bioluminescent Imaging of Murine Gliomas
Published on: November 6, 2011
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Quantitative sodium imaging and gliomas: a feasibility study.
Lucidio P Nunes Neto1, Guillaume Madelin1, Terlika Pandit Sood1
1Department of Radiology, New York University School of Medicine, 660 1st Avenue, New York, 10016, NY, USA.
Neuroradiology
|June 5, 2018
Summary
Quantitative sodium MRI can assess gliomas. This study found increased total sodium and extracellular volume in gliomas, confirming sodium MRI
Area of Science:
- Neuroimaging
- Oncology
- Biophysics
Background:
- Sodium brain MRI advances enable higher signal-to-noise ratio and faster imaging.
- Sodium metabolism is altered in gliomas, with increased total sodium and extracellular volume.
- Quantitative sodium MRI offers potential for clinical applications in glioma evaluation.
Purpose of the Study:
- To assess the feasibility of using quantitative sodium MRI measurements for glioma evaluation.
- To investigate alterations in sodium metabolism within gliomas.
Main Methods:
- Eight treatment-naïve glioma patients underwent 3T MRI with a 1H/23Na head coil.
- Maps of pseudo-intracellular sodium concentration (C1), pseudo-extracellular volume fraction (α2), apparent intracellular sodium concentration (aISC), and apparent total sodium concentration (aTSC) were generated.
- Measurements were taken in normal-appearing putamen, white matter (NAWM), and solid tumor regions; paired t tests were used for comparisons.
Main Results:
- Normal-appearing putamen showed significantly higher aTSC, aISC, C1, and α2 compared to NAWM.
- Solid tumors exhibited significantly higher aTSC and α2, and significantly lower aISC compared to NAWM.
- No significant difference in C1 was observed between solid tumors and NAWM.
Conclusions:
- Quantitative sodium MRI is feasible in glioma patients.
- Results provide further evidence for increased total sodium and extracellular volume fraction in gliomas.
- Sodium MRI offers a promising tool for glioma assessment.
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