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Phthalate exposure as a risk factor for hypertension.

Xueling Lu1, Xijin Xu1,2, Yucong Lin3,4

  • 1Laboratory of Environmental Medicine and Developmental Toxicology and Guangdong Provincial Key Laboratory of Infectious Diseases, Shantou University Medical College, Shantou, 515041, Guangdong, China.

Environmental Science and Pollution Research International
|June 5, 2018
PubMed
Summary

Phthalate exposure may be linked to hypertension in adults, but not children, according to this review. Further research is needed to understand the mechanisms and long-term effects of phthalates on blood pressure.

Keywords:
Blood pressureCardiovascular diseaseHypertensionPhthalatesRisk factor

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Area of Science:

  • Environmental Health
  • Toxicology
  • Cardiovascular Disease Epidemiology

Background:

  • Phthalates are widespread environmental contaminants.
  • Hypertension is a significant risk factor for cardiovascular diseases.
  • Previous studies suggest a link between phthalate exposure and hypertension.

Purpose of the Study:

  • To review and summarize scientific literature on the association between phthalate exposure and hypertension.
  • To discuss potential mechanisms underlying this relationship.
  • To identify research gaps in understanding phthalate's impact on blood pressure.

Main Methods:

  • Systematic literature review of studies published up to March 2018.
  • Searched PubMed and Web of Science using keywords related to phthalates, blood pressure, and hypertension.
  • Synthesized findings from ten population-based investigations and five toxicological experiments.

Main Results:

  • Epidemiological studies suggest a possible correlation between phthalate exposure and hypertension in adults.
  • One study indicated no association in children.
  • Experimental studies generally showed an increasing effect of phthalates on blood pressure.

Conclusions:

  • Phthalate exposure may be a risk factor for hypertension.
  • The impact of early-life phthalate exposure on later-life blood pressure remains unclear.
  • Longitudinal and molecular mechanism studies are essential for definitive conclusions.