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Global development and adaptive behaviour in children with early-onset epilepsy: a population-based case-control

Colin Reilly1,2, Patricia Atkinson3, Ayesha Memon3

  • 1Research Department, Young Epilepsy, Lingfield, Surrey, UK.

Developmental Medicine and Child Neurology
|June 5, 2018
PubMed

Insights

Children with early-onset epilepsy often experience developmental and adaptive behavior deficits. Non-white ethnicity and polytherapy are linked to poorer outcomes, suggesting unique neurodevelopmental profiles in these children.

Area of Science:

  • Pediatric Neurology
  • Developmental Psychology
  • Epileptology

Background:

  • Early-onset epilepsy (EOE) impacts child development.
  • Population-based data on EOE's developmental and adaptive behavior effects are scarce.
  • Understanding these impacts is crucial for early intervention.

Purpose of the Study:

  • Determine the prevalence of global developmental and adaptive behavior deficits in children with EOE.
  • Identify factors associated with these deficits.
  • Compare neurodevelopmental relationships in children with EOE versus those with other neurological conditions.

Main Methods:

  • Prospective, community-based study (Sussex Early Epilepsy and Neurobehaviour study).
  • Involved 48 children (1-7 years) with epilepsy and a matched control group.
  • Comprehensive psychological assessments including global development and adaptive behavior measures.

Main Results:

  • 71% of children with EOE showed delayed global development; 56% had adaptive behavior deficits.
  • Non-white ethnicity and polytherapy were independently associated with lower developmental scores.
  • Higher correlations between neurodevelopmental measures were observed in the epilepsy group.

Conclusions:

  • Children with EOE frequently exhibit global developmental and adaptive behavior challenges.
  • The neurodevelopmental profile in EOE differs from other conditions, impacting neuropathology and interventions.
  • Polytherapy is linked to developmental impairment, but seizure parameters are not.
Abstract

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